Nateglinide 那格列奈
CAS 105816-04-4 MFCD00875706
化学结构图
SMILES: CC(C)[C@@H]1CC[C@H](CC1)C(=O)N[C@H](CC1=CC=CC=C1)C(O)=O
化学属性
| Mol. Formula | C19H27NO3 |
|---|---|
| Mol. Weight | 317 |
| Melting Point | 136-140 |
别名和识别编码
| Chemical Name | Nateglinide |
|---|---|
| Synonym | AY 4166 Fastic N-[(trans-4-isopropylcyclohexyl)carbonyl]-D-phenylalanine Starlix Starsis N-[(trans-4-Isopropylcyclohexyl)carbonyl]-D-phenylalanine N-[(trans-4-isopropylcyclohexyl)carbonyl]-D-phenylalanine Nateglinide Starlix Starsis |
| MDL Number | MFCD00875706 |
| Chemical Name Translation | 那格列奈 |
| Beilstein Registry Number | 6486870 |
| CAS Number | 105816-04-4 |
| PubChem Substance ID | 160871031 |
| Reaxys-RN | 6486870 |
| Merck Number | 6428 |
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分类
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Calcium Channel Modulators, Cell Biology, Cell Signaling and Neuroscience, Inhibitors and Activators, Ion Channels, N, Novartis, Voltage-gated Ion Channels
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Calcium Channel Modulators, Inhibitors and Activators, Ion Channels, N, Novartis, Voltage-gated Ion Channels, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
相关文献及参考
- [2]. Shiling Hu, et al. Interaction of nateglinide with KATP channel in h-cells underlies its unique insulinotropic action. European Journal of Pharmacology. 442 (2002) 163-171.
- [3]. Jian Luo, et al. Evaluating insulin secretagogues in a humanized mouse model with functional human islets. Metabolism. 2013 Jan;62(1):90-9.
- [4]. Duffy NA, et al. Effects of antidiabetic drugs on dipeptidyl peptidase IV activity: nateglinide is an inhibitor of DPP IV and augments the antidiabetic activity of glucagon-like peptide-1. Eur J Pharmacol. 2007 Jul 30;568(1-3):278-86.
- [1]. Christopher J. Dunn, et al. Nateglinide. OFILE Drugs 2000 Sep: 60 (3): 6.
- [1]. Christopher J. Dunn, et al. Nateglinide. OFILE Drugs 2000 Sep: 60 (3): 6.
- [2]. Shiling Hu, et al. Interaction of nateglinide with KATP channel in h-cells underlies its unique insulinotropic action. European Journal of Pharmacology. 442 (2002) 163-171.
- [3]. Jian Luo, et al. Evaluating insulin
安全信息
GHS Symbol
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 25(Suppl 1),S5,1997
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Gastrointestinal - nausea or vomiting REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 25(Suppl 1),S9,1997
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 27 gm/kg
SEX/DURATION : female 17-22 day(s) after conception
lactating female 1-21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 25(Suppl 1),S139,1997