AKN-028
CAS 1175017-90-9 MFCD275017909
化学结构图
SMILES: Nc1ncc(-c2ccncc2)nc1Nc1ccc2[nH]ccc2c1
化学属性
| Mol. Weight | 302.33 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | AKN-028 |
|---|---|
| Formula | C17H14N6 |
| Synonym | AKN-028; AKN 028; AKN028 |
| IUPAC Name | N2-(1H-indol-5-yl)-6-(pyridin-4-yl)pyrazine-2,3-diamine |
| InChIKey | JLRIJKVMMZEKDF-UHFFFAOYSA-N |
| InChI | InChI=1S/C17H14N6/c18-16-17(22-13-1-2-14-12(9-13)5-8-20-14)23-15(10-21-16)11-3-6-19-7-4-11/h1-10,20H,(H2,18,21)(H,22,23) |
| Canonical SMILES | NC1=NC=C(C2=CC=NC=C2)N=C1NC3=CC4=C(NC=C4)C=C3 |
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产品应用
- AKN-028, the FLT3/KIT kinase inhibitor, is an orally bioavailable protein tyrosine kinase inhibitor for FMS-related tyrosine kinase 3 (FLT3; STK1) and stem cell factor receptor (SCFR; KIT), with potential antineoplastic activity. FLT3/KIT kinase inhibitor AKN-028 binds to and inhibits both the wild-type and mutated forms of FLT3 and SCFR. This may result in an inhibition of tumor cell proliferation in cancer cell types that overexpress these receptor tyrosine kinases. Check for active clinical trials or closed clinical trials using this agent.
