(1α,2β,4β,5α,7β)-7-[(Hydroxydi-2-thienylacetyl)oxy]-9,9-di-methyl-3-oxa-9-azoniatricyclo[3.3.1.0]nonane bromide (1α,2β,4β,5α,7β)-7-[2-羟基-2,2-二(2-噻吩基)乙酰氧]-9,9-二甲基-3-氧杂-9-氮阳离子三环[3.3.1.0]壬烷溴化物
CAS 136310-93-5 MFCD00867027
化学结构图
SMILES: [Br-].C[N+]1(C)[C@@H]2C[C@H](C[C@H]1[C@@H]1O[C@H]21)OC(=O)C(O)(C1=CC=CS1)C1=CC=CS1
化学属性
| Mol. Formula | C19H22BrNO4S2 |
|---|---|
| Mol. Weight | 472 |
别名和识别编码
| Chemical Name | (1α,2β,4β,5α,7β)-7-[(Hydroxydi-2-thienylacetyl)oxy]-9,9-di-methyl-3-oxa-9-azoniatricyclo[3.3.1.0]nonane bromide |
|---|---|
| CAS Number | 136310-93-5 |
| Synonym | (1?,2?,4?,5?,7?)-7-[(2-Hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane Bromide |
| Chemical Name Translation | (1α,2β,4β,5α,7β)-7-[2-羟基-2,2-二(2-噻吩基)乙酰氧]-9,9-二甲基-3-氧杂-9-氮阳离子三环[3.3.1.0]壬烷溴化物 |
| MDL Number | MFCD00867027 |
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分类
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Sulfur & Selenium Compounds,
产品应用
- Muscarinic receptor antagonist. Bronchodilator.
相关文献及参考
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- [3]. Lipson DA. Tiotropium bromide. Int J Chron Obstruct Pulmon Dis. 2006;1(2):107-14.
- [4]. Mamary AJ, Criner GJ. Tiotropium bromide for chronic obstructive pulmonary disease. Expert Rev Respir Med. 2009 Jun;3(3):211-20.
- [5]. Szmidt M. [The influence of treatment with formoterol, formoterol with tiotropium, formoterol with inhaled glucocorticosteroid and tiotropium on lung functions, tolerance of exercise and simple, morning everyday activities in patients with chronic obstructive pulmonary disease (COPD)]. Pneumonol Alergol Pol. 2012;80(3):255-62.
- Donohue, J. F., et al.: Chest, 122, 47 (2002),
- Haddad, E.-B., et al.: Mol. Pharmacol., 45, 899 (1994),
- Profita, M., et al.: Allergy, 60, 1361 (2005),
- [1]. Barnes PJ. Tiotropium
