(R)-N1-((S)-3-(1H-Indol-3-yl)-1-(Methylamino)-1-Oxopropan-2-yl)-N4-Hydroxy-2-Isobutylsuccinamide (R)-N1-((S)-3-(1H-吲哚-3-基)-1-(甲胺基)-1-氧代丙-2-基)-N4-羟基-2-异丁基琥珀酰胺
CAS 142880-36-2 MFCD00917040
化学结构图
SMILES: CC(C)C[C@H](CC(=O)NO)C(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(=O)NC
化学属性
| Mol. Formula | C20H28N4O4 |
|---|---|
| Mol. Weight | 388 |
别名和识别编码
| Chemical Name | (R)-N1-((S)-3-(1H-Indol-3-yl)-1-(Methylamino)-1-Oxopropan-2-yl)-N4-Hydroxy-2-Isobutylsuccinamide |
|---|---|
| Synonym | GM6001 GM6001 Galardin Ilomastat Galardin Ilomastat |
| PubChem Substance ID | 329818026 |
| CAS Number | 142880-36-2 |
| Chemical Name Translation | (R)-N1-((S)-3-(1H-吲哚-3-基)-1-(甲胺基)-1-氧代丙-2-基)-N4-羟基-2-异丁基琥珀酰胺 |
| MDL Number |
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分类
- {SNA} Application Index, Bioactive Small Molecule Alphabetical Index, Cell Signaling Enzymes, Cytoskeleton and Extracellular Matrix, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Extracellular Matrix, L to O, Matrix Metalloproteinases Products, Matrix metalloprotease, Metalloproteinase Inhibitors, N, Other MMP Inhibitors, Protease Inhibitor Specificity Index, Protease Inhibitors, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
相关文献及参考
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- [3]. Li C, et al. Arterial repair after stenting and the effects of GM6001, a matrix metalloproteinase inhibitor. J Am Coll Cardiol. 2002 Jun 5;39(11):1852-8.
- [4]. Leppert D, et al. T cell gelatinases mediate basement membrane transmigration in vitro. J Immunol. 1995 May 1;154(9):4379-89.
- [5]. Yamamoto M, et al. Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket. J Med Chem. 1998 Apr 9;41(8):1209-17.
- [1]. Grobelny D, et al. Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeru
- [1]. Grobelny D, et al. Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry. 1992 Aug 11;31(31):7152-4.
