CAS 146-22-5 MFCD00058577-2H-1,4-Benzodiazepin-2-one,1,3-dihydro-7-nitro-5-phenyl- 硝西泮溶液，100ppm TAO{mole}

2H-1,4-Benzodiazepin-2-one,1,3-dihydro-7-nitro-5-phenyl- 硝西泮溶液，100ppm

CAS 146-22-5 MFCD00058577

化学结构图

SMILES: [O-][N+](=O)C1C=C2C(=NCC(=O)NC2=CC=1)C1C=CC=CC=1

化学属性

Mol. Formula	C15H11N3O3
Mol. Weight	281.29
Appearance	淡黄色片状结晶。熔点226-229℃（分解）。溶于乙醇、丙酮、氯仿、乙酸乙酯、二氯甲烷，不溶于水、乙醚、苯和已烷。无臭，无味。

别名和识别编码

Chemical Name	Nitrazepam
CAS Number	146-22-5
Synonym	1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one Sonnolin Mogadan 1,3-dihydro-7-nitro-5-phenyl-2h-4-benzodiazepin-2-one 5-苯基-7-硝基-1,3-二氢-2H-1,4-苯并二氮卓-2-酮 Eunoktin Hipsal Dormin-5 Neozepam 7-Nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one 7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one 7-Nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one NITRAZEPAM Hipnax Nitrados Ro 5-3059 Epinelbon Ro 4-5360 Mogadon Dumolid Apodorm 1,3-二氢-7-硝基-5-苯基-2H-1,4-苯并二氮杂酮-2 Paxisyn 5-苯基-7-硝基-1,3-二氢-2H-1,4-苯并二氮杂卓-2-酮 Benzalin Nitrenpax 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-nitro-5-phenyl- 硝基安定 Relact 消酮 NSC-58775 Mogadone 1H-1,4-Benzodiazepin-2(3H)-one, 7-chloro-3-isopropyl-5-phenyl- Eunoctin Radedorm 1,3-dihydro-7-nitro-5-phenyl-2h-1,4-benzodiazepin-2-one LA 1 Cerson Eatan Nitrazepam Pelson 硝西泮 Calsmin Epibenzalin
MDL Number	MFCD00058577
PubChem Substance ID	24897666
EC Number	205-665-2
Chemical Name Translation	硝西泮溶液，100ppm
Wiswesser Line Notation	T67 GMV JN IHJ CNW KR
Beilstein Registry Number	0757185

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

Anticonvulsant; hypnotic.

安全信息

WGK Germany3

GHS Symbol

Hazard statements

H302 Harmful if swallowed 吞食有害

RTECSDF2450000

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes Xn

Safety Statements

S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Risk Statements

R22 Harmful if swallowed 吞咽有害

Packing GroupIII

Hazard Class6.1(b)

UN Number 3249

Restrict {} 精神药品精麻类化学品

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 825 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 520 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,165,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >400 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
REFERENCE :
   SMWOAS Schweizerische Medizinische Wochenschrift.  (Schwabe & Co.,
   Steintorst 13, 4010 Basel, Switzerland)  V.50-    1920-
   Volume(issue)/page/year: 95,334,1965

TYPE OF TEST

TYPE OF TEST            : LD50 - Lethal dose, 50 per

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 733 mg/kg
TOXIC EFFECTS :
   Behavioral - anticonvulsant
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 20,952,1977

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1667 ug/plate
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 18,12,1987

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 2 mg/9D
REFERENCE :
   SOGEBZ Soviet Genetics.  English translation of GNKAA5.  (Plenum Pub. Corp.,
   233 Spring St., New York, NY 10013)  V.2-    1966- Volume(issue)/page/year:
   11,718,1975

TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 5000 PPM
REFERENCE :
   CUSCAM Current Science.  (Current Science Assoc., Sadashivanagar P.O.,
   Bangalore 560 080, India) V.1-    1932-  Volume(issue)/page/year:
   57,682,1988

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 300 mg/kg/15D (Continuous)
REFERENCE :
   CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK)  V.1- 1969- 
   Volume(issue)/page/year: 36,45,1983

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 300 mg/kg/15D (Intermittent)
REFERENCE :
   INDRBA Indian Drugs.  (Indian Drugs Manufacturers' Assoc., 102B, Poonam
   Chambers, Dr. A. B. Rd., Worli, Bombay 400 018, India)  V.1-    1963-
   Volume(issue)/page/year: 22,410,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 100 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 46,437,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 200 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 69,59,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 300 mg/kg
SEX/DURATION            : female 12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 69,59,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE

其他信息

图谱信息:硝西泮(146-22-5)核磁图( 13 CNMR) 硝西泮(146-22-5)质谱(MS) 硝西泮(146-22-5)红外图谱(IR2) 硝西泮(146-22-5)红外图谱(IR1) 硝西泮(146-22-5)核磁图( 1 HNMR)
上游原料:乌洛托品 --> 苯甲酰氯 --> 氯乙酰氯 --> 4-氯苯胺 --> 氯乙酰胺 --> 2-氨基-5-硝基二苯甲酮
方法一:2-氨基-5-硝基二苯酮（见02420）溶于干燥的苯，搅拌下滴加氯乙酰氯，升温回流4h，生成2-氯乙酰胺基-5-硝基二苯酮。将基与六次甲基四胺和乙醇加热回流20h，然后蒸馏回收乙醇，过滤得到粗品，再经脱以重结晶，得硝西泮成品。
MOL 文件:146-22-5.mol
Sigma Aldrich:146-22-5(sigmaaldrich)
用途一:该品为苯二氮类药，具有催眠、松驰肌肉、抗惊厥和抗焦虑作用。服药15-30min入睡，持续6-8h，接近自然睡眠。