4-(Tert-Butyl)-N-(6-(2-Hydroxyethoxy)-5-(2-Methoxyphenoxy)-[2,2'-Bipyrimidin]-4-Yl)Benzenesulfonamide 4-(叔丁基)-N-(6-(2-羟基乙氧基)-5-(2-甲氧基苯氧基)-[2,2’-联吡啶]-4-基)苯磺酰胺
CAS 147536-97-8 MFCD00867375
化学结构图
SMILES: COC1=CC=CC=C1OC1C(NS(=O)(=O)C2=CC=C(C=C2)C(C)(C)C)=NC(=NC=1OCCO)C1=NC=CC=N1
化学属性
| Mol. Formula | C27H29N5O6S |
|---|---|
| Mol. Weight | 552 |
别名和识别编码
| Chemical Name | 4-(Tert-Butyl)-N-(6-(2-Hydroxyethoxy)-5-(2-Methoxyphenoxy)-[2,2'-Bipyrimidin]-4-Yl)Benzenesulfonamide |
|---|---|
| CAS Number | 147536-97-8 |
| Synonym | 4-(tert-Butyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide Monohydrate |
| Beilstein Registry Number | \u00099031515 |
| Chemical Name Translation | 4-(叔丁基)-N-(6-(2-羟基乙氧基)-5-(2-甲氧基苯氧基)-[2,2’-联吡啶]-4-基)苯磺酰胺 |
| MDL Number | MFCD00867375 |
| Reaxys-RN | 9031515 |
| Merck Number | 1353 |
| PubChem Substance ID | 354334055 |
信息真实价格透明
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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现货库存
一流品牌服务
分类
- Aromatics
- Heterocycles
- Nucleotides
- Bases & Related Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Sulfur & Selenium Compounds
产品应用
- A mixed endothelin receptor antagonist. Used as a vasodilator. Antihypertensive.
相关文献及参考
- [2]. Akamata K, et al. Bosentan reverses the pro-fibrotic phenotype of systemic sclerosis dermal fibroblasts via increasing DNA binding ability of transcription factor Fli1. Arthritis Res Ther. 2014 Apr 3;16(2):R86.
- [3]. Iglarz M, et al. Comparison of pharmacological activity of macitentan and bosentan in preclinical models of systemic and pulmonary hypertension. Life Sci. 2014 Nov 24;118(2):333-9.
- [4]. Son GY, et al. Endothelin Regulates Porphyromonas gingivalis-Induced Production of Inflammatory Cytokines. PLoS One. 2016 Dec 28;11(12):e0167713.
- Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994),
- Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1996),
- Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1996),
- [1]. Dhillon S, et al. Bosentan:
- [1]. Dhillon S, et al. Bosentan: a review of its use in the management of mildly symptomatic pulmonary arterial hypertension. Am J Cardiovasc Drugs. 2009;9(5):331-50.
安全信息
GHS Symbol
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312
- P308+P313
- P330 Rinse mouth. 漱口
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
