Naltrexone Hydrochloride 盐酸纳曲酮
CAS 16676-29-2 MFCD00069324
化学结构图
SMILES: Cl.O[C@]12CCC(=O)[C@@H]3OC4=C5C(C[C@H]1N(CC1CC1)CC[C@]253)=CC=C4O
化学属性
| Mol. Formula | C20H23NO4.ClH |
|---|---|
| Mol. Weight | 377.90 |
| TSCA | No |
别名和识别编码
| Chemical Name | Naltrexone Hydrochloride |
|---|---|
| CAS Number | 16676-29-2 |
| Synonym | 17-(Cyclopropylmethyl)-4,5-alpha-epoxy-3,14-dihydroxy-morphinan-6-one (5?)-17-(Cyclopropyl-methyl-d3)-4,5-epoxy-3,14-dihydroxymorphinan-6-one Hydrochloride Naltrexone hydrochloride Trexan Nalorex (5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride Antaxone EN 1639A Depade NIH 8503 |
| MDL Number | MFCD00069324 |
| Beilstein Registry Number | 3580333 |
| EC Number | 240-723-0 |
| PubChem Substance ID | 24278051 |
| Merck Number | 14,6363 |
| Wiswesser Line Notation | T B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ CQ JQ P1-AL3TJ &GH |
| Chemical Name Translation | 盐酸纳曲酮 |
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分类
- Chiral Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals,
- {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates, N, Other
产品应用
- Nonselective opioid receptor antagonist; congener of Naloxone.
相关文献及参考
- Maickel, R.P., et al.: Ann. N.Y. Acad. Sci., 281, 321 (1976),
- Gritz, E.R., et al.: Clin. Pharmacol. Ther. 19, 773 (1976),
- Gonzales, J.P., et al.: Drugs, 35, 192 (1988),
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- S22 Do not breathe dust 不要吸入粉尘；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- R22 Harmful if swallowed 吞咽有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1450 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 21,264,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 3 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 21,264,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 21,264,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 1490 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 21,264,1985
TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Human Fibroblast DOSE/DURATION : 100 mg/L REFERENCE : DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 1,103,1978
TYPE OF TEST : DNA repair TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 100 mg/L REFERENCE : DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 1,103,1978
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 1100 mg/kg SEX/DURATION : female 1-22 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : PHBHA4 Physiology and Behavior. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1966- Volume(issue)/page/year: 62,501,1997
