5α-Androstane-3α,17β-diol 5a-Androstane-3a,17b-diol
CAS 1852-53-5 MFCD00003676
化学结构图
SMILES: C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](O)CC[C@@]43C)[C@@H]1CC[C@@H]2O
化学属性
| Mol. Formula | C19H32O2 |
|---|---|
| Mol. Weight | 292.51 |
别名和识别编码
| Chemical Name | 5a-雄甾烷-3a,17b-二醇 |
|---|---|
| CAS Number | 1852-53-5 |
| Synonym | Hombreol DIHYDROANDROSTANEDIOL (3R,5S,8R,10S,13S,17S)-10,13-Dimethyl-hexadecahydro-cyclopenta[a]phenanthrene-3,17-diol Adiol Androstane-3,17-diol, (3alpha,5alpha,17beta)- 5ALPHA-Androstane-3ALPHA,17B-diol 3?,17?-Dihydroxy-5?-androstane 5α-雄甾烷-3α,17β-二醇 3α,17β-dihydroxy-5α-androstane Androstane-3alpha,17beta-diol 5α-雄甾烷-3α,17β-二醇 Etiocholane-3alpha,17beta-diol 10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol Androstane-3?,17?-diol 3α,17β-二羟基-5α-雄甾烷 二氢雄甾酮 3ALPHA,17BETA-DIHYDROXY-5ALPHA-ANDROSTANE 5A-雄甾烷-3A 17B-二醇 5a-雄甾烷-3a,17b-二醇 Androstane-3,17-diol, (3-alpha,5-alpha,17-beta)- 5-α-androstane-3-α,17-β-diol 3a,17b-dihydroxy-5a-androstane (3-alpha,5-alpha,17-beta)-androstane-17-diol 5A-ANDROSTAN-3A,17SS-DIOL 5-alpha-androstane-3-alpha,17-beta-diol; 3alpha,17beta-Dihydroxy-5alpha-androstane; 3a,17b-Dihydroxy-5a-androstane 3Α,17-二羟基-5Β-雄甾烷 17-BETA-DIHYDROANDROSTERONE 5alpha-Androstan-3alpha,17beta DIHYDRO-ANDROSTERONE 5ALPHA-ANDROSTAN-3ALPHA,17BETA-DIOL 雄烷二羟基 5ALPHA-ANDROSTANE-3ALPHA,17BETA-DIOL Etiocholane-3?,17?- 5alpha-Androstane-3alpha,17beta-androstanediol 5a-androstane-3a,17b-diol 3-alpha,17-beta-Dihydroxy-5-alpha-androstane 5A-ANDROSTAN-3A,17B-DIOL 3?,5?-Tetrahydrotestosterone (3R,5S,8R,10S,13S,17S)-10,13-Dimethyl-hexadecahydro-cyclopenta[a]phenanthrene-3,17-diol (3?,5?,17?)-Androstane-3,17-diol |
| MDL Number | MFCD00003676 |
| PubChem Substance ID | 15818 |
| EC Number | 217-447-4 |
| Chemical Name Translation | 5a-Androstane-3a,17b-diol |
| Beilstein Registry Number | 2694353 |
| InChI | InChI=1S/C19H32O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-17,20-21H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,17-,18-,19-/m0/s1 |
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分类
- AN-AZ, Androgen, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Steroid Hormones
- {uni_hamburg} no charge; carbocycle; alicycle; large ring; fused rings; 5ring; 6ring; 9ring; 10ring; 13ring; 14ring; 17ring; alcohol; chiral; 1fragment
- {SNA} AN-AZ, Androgen, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Steroid Hormones
产品应用
- A metabolite of Testosterone (T155000).
相关文献及参考
- Kulkarni, S., et al.: Xenobiotica, 35, 955 (2005),
- Kicman, A., et al.: Br. J. Pharmacol., 154, 502 (2008),
- Fragkaki, A., et al.: Steroids, 74, 172 (2009),
- Biswas, M.G., et al. J. Biol. Chem. 272 , 15959, (1997) 摘要
- Garnier, D.H., et al. Gen. Comp. Endocrinol. 116 , 281, (1999) 摘要
- Wasson, K.M., et al. Gen. Comp. Endocrinol. 111 , 197, (1998) 摘要
- Liu, W., et al., An improved hollow fiber solvent-stir bar microextraction for the preconcentration of anabolic steroids in biological matrix with determination by gas chromatography-mass spectrometry J. Chromatogr. A. 1233 , 1-7, (2012)
- Ahlem, C., et al., 17α-ethynyl-5α-androstane-3α, 17β-diol treatment of MNU-induced mammary cancer in rats Int. J. Breast Cancer , doi: 10.4061/2011/618757, (2011)
- Jegham, H., et al., Biological evaluation of a new family of aminosteroids that display a selective toxicity for various malignant cell lines Anti-Cancer Drugs 23(8) , 803-14, (2012)
- Short: III/35E Title: Nuclear Magnetic Resonance (NMR) Data: Chemical Shifts for Oxygen-17 Author: Duddeck, H.; Toth, G.; Simon, A. Editor: Gupta, R.R.; Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: III/35E Year: 2002 Keyword: Alipathic and Aromatic hydrocarbons; Coupling constant j; Nuclear Magnetic Resonance; chemical shifts δ ISBN: 3-540-42501-2 ISBN: 978-3-540-42501-4 Internet Resource: DOI:10.1007/b92953 RefComment: VII, 230 pages. With CD-ROM., Hardcover Abstract: This volume provides a comprehensive and evaluated compilation of nuclear magnetic resonance data. Chemical shifts and coupling constants of boron-11 and phosphorus-31 (subvol. A), fluorine-19 and nitrogen-15 (subvol. B), hydrogen-1 (subvol. C), carbon-13 (subvol. D), and oxygen-17 (subvol. E) compounds are tabulated together with the gross- and structure formulas
安全信息
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 48 mg/kg SEX/DURATION : male 6 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : JSTBBK Journal of Steroid Biochemistry. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 0BW, UK) V.1- 1969- Volume(issue)/page/year: 18,397,1983
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Primate - monkey DOSE : 200 ug/kg SEX/DURATION : male 20 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 89,69,1990
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE : 8 mg/kg SEX/DURATION : female 13-20 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 99,1490,1976
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE : 40 mg/kg SEX/DURATION : female 13-20 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - ski
其他信息
- 用途一:用作合成性激素的原料
- MOL 文件:1852-53-5.mol
- Sigma Aldrich:1852-53-5(sigmaaldrich)
