(E)-5-Chloro-2-(2-(Phenyl(Pyridin-2-Yl)Methylene)Hydrazinyl)Pyridine (E)-5-氯-2-(2-(苯基(吡啶-2-基)亚甲基)肼基)吡啶
CAS 199596-05-9 MFCD99596059
化学结构图
SMILES:
化学属性
| Mol. Weight | 308.76 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | (E)-5-氯-2-(2-(苯基(吡啶-2-基)亚甲基)肼基)吡啶 |
|---|---|
| Chemical Name | (E)-5-Chloro-2-(2-(Phenyl(Pyridin-2-Yl)Methylene)Hydrazinyl)Pyridine |
| Formula | C17H13ClN4 |
| Synonym | JIB04; JIB-04; JIB 04; NSC 693627; NSC-693627; NSC 693627. |
| IUPAC Name | (E)-5-chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine |
| InChIKey | YHHFKWKMXWRVTJ-OQKWZONESA-N |
| InChI | InChI=1S/C17H13ClN4/c18-14-9-10-16(20-12-14)21-22-17(13-6-2-1-3-7-13)15-8-4-5-11-19-15/h1-12H,(H,20,21)/b22-17+ |
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产品应用
- JIB-04, also known as NSC 693627, is a Jumonji histone demethylase inhibitor. JIB-04 selectively blocks cancer cell growth in vitro and diminishes tumor growth in H358 and A549 mouse xenograft models in vivo. JIB-04 can prolong survival in a mouse model of breast cancer.
