5-Fluoroorotic Acid Hydrate 5-氟乳清酸水合物
CAS 207291-81-4 MFCD00150658
化学结构图
SMILES:
化学属性
| Mol. Formula | C5H3FN2O4· xH2O |
|---|---|
| Mol. Weight | 174.09 (anhydrous basis) |
| Melting Point | 278 °C (dec.)(lit.) |
| TSCA | No |
别名和识别编码
| Chemical Name | 5-Fluoroorotic Acid Hydrate |
|---|---|
| CAS Number | 207291-81-4 |
| Alfabeta Name | FLUOROOROTICACIDMONOHYDRATE 5- |
| MDL Number | MFCD00150658 |
| Synonym | 1,2,3,6-Tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylic acid 2,6-Dihydroxy-5-fluor-pyrimidin-4-carbonsäure 5-Fluor-uracil-4-carbonsäure 4-Pyrimidinecarboxylic acid, 5-fluoro-1,2,3,6-tetrahydro-2,6-dioxo- 5-Fluoroorotate 5-Fluoroorotic acid 5-Fluoroorotic acid hydrate 5-Fluorouracil-6-carboxylic acid monohydrate ENT-26398 FO FOA Fluoroorotic acid NSC 31712 Orotic acid, 5-fluoro- Ro 2-9945 |
| PubChem Substance ID | 24894877 |
| EC Number | 211-876-0 |
| Reaxys-RN | 181933 |
| Beilstein Registry Number | 25(5)8,240 |
| Merck Number | 4176 |
| Chemical Name Translation | 5-氟乳清酸水合物 |
| Wiswesser Line Notation | T6VMVMJ EVQ FF |
分类
- {SA} Building Blocks, C4 to C5, Chemical Synthesis, Heterocyclic Building Blocks, Pyrimidines
- Activity, Biochemicals and Reagents, Enzyme Substrates, Enzymes, Inhibitors, and Substrates, Fluorogenic
- {SNA} Activity, Enzyme Substrates, Fluorogenic, 生化试剂, 酶、抑制剂和底物
- {SNA} Activity, Biochemicals and Reagents, Enzyme Substrates, Enzymes, Inhibitors, and Substrates, Fluorogenic
相关文献及参考
- Beil. 25 ,IV,1763
- Merck 14 ,4176
- Potential antimalarial agent: Antimicrob. Agents Chemother., 40, 914 (1996).
- Reagent used in the selection of mutant URA3 gene strains of Saccharomyces Cerevisiae: Genetics, 107, 179 (1984); Methods Enzymol., 154, 164 (1987).
- Structure Index 1 , 409:E:2
- Winston, F., et al. Genetics 107 , 179, (1984) 摘要
安全信息
GHS Symbol
- P301+P312+P330
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H302 Harmful if swallowed 吞食有害
- H319 Causes serious eye irritation 严重刺激眼睛
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R22 Harmful if swallowed 吞咽有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued. Volume(issue)/page/year: 3,181,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 981 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
