CAS 208255-80-5 MFCD04974585-((S)-Tert-Butyl 2-((S)-2-(2-(3,5-Difluorophenyl)Acetamido)Propanamido)-2-Phenylacetate) (2S)-N-[N-(3,5-二氟苯乙酰基)-L-丙氨酰]-2-苯基甘氨酸叔丁酯 TAO{mole}

((S)-Tert-Butyl 2-((S)-2-(2-(3,5-Difluorophenyl)Acetamido)Propanamido)-2-Phenylacetate) (2S)-N-[N-(3,5-二氟苯乙酰基)-L-丙氨酰]-2-苯基甘氨酸叔丁酯

CAS 208255-80-5 MFCD04974585

化学结构图

SMILES: C[C@@H](NC(=O)CC1C=C(F)C=C(F)C=1)C(=O)N[C@@H](C(=O)OC(C)(C)C)C1C=CC=CC=1 |&1:1,17|

化学属性

Mol. Formula	C23H26F2N2O4
Mol. Weight	432

别名和识别编码

Chemical Name	((S)-Tert-Butyl 2-((S)-2-(2-(3,5-Difluorophenyl)Acetamido)Propanamido)-2-Phenylacetate)
Synonym	(3,5-Difluorophenylacetyl)-L-alanyl-L-2-phenylglycine tert-Butyl Ester DAPT
MDL Number	MFCD04974585
PubChem Substance ID	253659655
CAS Number	208255-80-5
Reaxys-RN	9588440
Chemical Name Translation	(2S)-N-[N-(3,5-二氟苯乙酰基)-L-丙氨酰]-2-苯基甘氨酸叔丁酯
Beilstein Registry Number	9588440
LabNetwork Molecule ID	LN01277592

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相关文献及参考

Micchelli, C.A., et al., γ-Secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila . FASEB J. 17 , 79-81, (2003) 摘要
Teachey DT, et al., Targeting Notch signaling in autoimmune and lymphoproliferative disease Blood 111 , 705-714, (2008) 摘要
Kanungo J, et al., The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins J. Neurochem. 106 , 2236-2248, (2008) 摘要
Zhang H, et al., The COX-2 selective inhibitor-independent COX-2 effect on colon carcinoma cells is associated with the Delta1/Notch1 pathway Dig. Dis. Sci. 53 , 2195-2203, (2008) 摘要
Sato T, et. al., A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis. Proc. Natl. Acad. Sci. U. S. A. , 1421-6, (2009) 摘要
Trombly, D.J., et al., Suppression Of Notch Signaling In The Neonatal Mouse Ovary Decreases Primordial Follicle Formation. Endocrinology 150 , 1014-24, (2009) 摘要
Zhang, C.P., et al., Notch Signaling Is Involved In Ovarian Follicle Development By Regulating Granulosa Cell Proliferation. Endocrinology 152 , 2437-47, (2011) 摘要
Micchelli, C.A., et al., γ-Secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila . FASEB J. 17 , 79-81, (2003) 摘要
Lammich, S., et al., Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide. J. Biol. Chem. 277 , 44754-44759, (2002) 摘要
Dovey, H.F., et al., Functional γ-secretase inhibitors reduce β-amyloid peptide levels in brain. J. Neurochem. 76 , 173-181, (2001) 摘要

安全信息

WGK Germany3

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Storage condition 0-10°C

GHS Symbol

Safety Statements

S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；

Precautionary statements

P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。