N-(2-(6-Hydroxy-5-Methoxy-1H-Indol-3-Yl)Ethyl)Acetamide N-(2-(6-羟基-5-甲氧基-1H-吲哚-3-基)乙基)乙酰胺
CAS 2208-41-5 MFCD00037971
化学结构图
SMILES: COc1cc2c(CCNC(C)=O)c[nH]c2cc1O
化学属性
| Mol. Formula | C13H16N2O3 |
|---|---|
| Mol. Weight | 248.31 |
别名和识别编码
| Chemical Name | N-(2-(6-Hydroxy-5-Methoxy-1H-Indol-3-Yl)Ethyl)Acetamide |
|---|---|
| CAS Number | 2208-41-5 |
| Synonym | 6-Hydroxymelatonin 3-(N-Acetylaminoethyl)-6-hydroxy-5-methoxyindole Acetamide, N-(2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl)- N-[2-(6-Hydroxy-5-methoxy-1H-indol-3-yl)ethyl]acetamide |
| MDL Number | MFCD00037971 |
| PubChem Substance ID | 1864 |
| Chemical Name Translation | N-(2-(6-羟基-5-甲氧基-1H-吲哚-3-基)乙基)乙酰胺 |
| Beilstein Registry Number | 0483231 |
| LabNetwork Molecule ID | LN01286734 |
| InChI | InChI=1S/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16) |
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分类
- Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, H, Meatonin - Receptor Agonists, Melatonins, Membrane Protein Biology Tools, Neurobiology, Neuroscience, Pharmacologicals, Proteins and Derivatives
- {SA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, H, Meatonin - Receptor Agonists, Melatonins, Membrane Protein Biology Tools,
- {SNA} Bioactive Sm
产品应用
- A metabolite of Melatonin (M215000).
相关文献及参考
- Huether, G., et al.: Life Sci., 51, 945
- Pang, C.S., et al., Comparison of the pharmacological characteristics of 2-[ 125 I]iodomelatonin binding sites in the lung, spleen, brain and kidney of chicken. Biol. Signals 4 , 311, (1995) 摘要
- Ting, K.N, et al., Studies on the vasoconstrictor action of melatonin and putative melatonin receptor ligands in the tail artery of juvenile Wistar rats. Br. J. Pharmacol. 122 , 1299-1306, (1997) 摘要
- [1]. Härtter S, et al. Orally given melatonin may serve as a probe drug for cytochrome P450 1A2 activity in vivo: a pilot study. Clin Pharmacol Ther. 2001 Jul;70(1):10-6.
安全信息
GHS Symbol
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- H351 Suspected of causing cancer 怀疑致癌
- H302 Harmful if swallowed 吞食有害
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 8 mg/kg SEX/DURATION : male 20 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 33,618,1985
