Sodium (S)-2-Hydroxy-2-(8-(Hydroxymethyl)-9-Oxo-9,11-Dihydroindolizino[1,2-B]Quinolin-7-Yl)Butanoate (S)-2-羟基-2-(8-(羟甲基)-9-氧代-9,11-二氢吲哚并[1,2-b]喹啉-7-基)丁酸钠
CAS 25387-67-1 MFCD01745315
化学结构图
SMILES: [Na+].CC[C@@](O)(C([O-])=O)C1C=C2C3N=C4C=CC=CC4=CC=3CN2C(=O)C=1CO
化学属性
| Mol. Formula | C20H18N2O5.Na |
|---|---|
| Mol. Weight | 389.39 |
别名和识别编码
| Chemical Name | Sodium (S)-2-Hydroxy-2-(8-(Hydroxymethyl)-9-Oxo-9,11-Dihydroindolizino[1,2-B]Quinolin-7-Yl)Butanoate |
|---|---|
| Synonym | sodium camptothecin Sodium camptothecin NSC-100880 Camptothecine sodium 21,22-Secocamptothecin-21-oic acid, monosodium salt |
| MDL Number | MFCD01745315 |
| Wiswesser Line Notation | T F6 D6 C566 BN HVO LVN NHT&&&&J GQ G2 |
| CAS Number | 25387-67-1 |
| Chemical Name Translation | (S)-2-羟基-2-(8-(羟甲基)-9-氧代-9,11-二氢吲哚并[1,2-b]喹啉-7-基)丁酸钠 |
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分类
- {SNA} Alcohols, Amines, Building Blocks, C11 to C30+, C20 to C30+, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks, Oxygen Compounds
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 57 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 27 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 151 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GTKRDX Gan to Kagaku Ryoho. Cancer and Chemotherapy. (1-8-9 Yaesu, Chuo-ku, Tokyo 103, Japan) V.1- 1974- Volume(issue)/page/year: 14,850,1987
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human DOSE/DURATION : 2500 ug/kg/7D-I TOXIC EFFECTS : Blood - leukopenia Blood - thrombocytopenia Blood - changes in cell count (unspecified) REFERENCE : CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC) V.52(6)-59, 1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 56,515,1972
