Fluorescein isothiocyanate isomer 1 异硫氰酸荧光素酯

CAS 3326-32-7 MFCD00005063

化学结构图

3326-32-7
SMILES: O=C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccc(N=C=S)cc21

化学属性

Mol. FormulaC21H11NO5S
Mol. Weight389.38
Melting Point>360
Density1.54
TSCAYes
Appearance powder 黄色粉末,能溶于水,在水中分解。易溶于碱性水溶液,并呈强列的绿色荧光消失,并析出沉淀,加碱后又溶解并出现荧光。难溶于丙酮,乙醚及石油醚。有吸湿性。
Stability对光线,湿度和热敏感
Solubilitypractically insoluble
Boiling Point~708.6 °C at 760 mmHg

别名和识别编码

Chemical NameFluorescein isothiocyanate isomer 1
Synonym 2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-5-ISOTHIOCYANATO-BENZOIC ACID 5 Isothiocyanatofluorescein 5-FLUORESCEIN ISOTH 5-FLUORESCEIN ISOTHIOCYANATE 5-Isothiocyanatofluorescein F FITC {Chemicalbook} FITC ISOMER FLUORESCEIN 5(6)-ISOTHIOCYANATE FLUORESCEIN 5-ISOTHIOCYANATE, ISOMER 1 FLUORESCEIN ISOMER I ISOTHIOCYANATE FLUORESCEIN ISOTHIOCYANATE ISOMER I FLUORESCEIN ISOTHIOCYANATE, ISOMER 1 FLUORESCEIN-5-ISOTHIOCYANATE ISOMER I Fluorescein (5 or 6)-Isothiocyanate Fluorescein 5 isothiocyanate Fluorescein 5 isothiocyanate Hydrochloride Fluorescein 5-isothiocyanate Fluorescein-5-isothiocyanate Fluorescein-5-isothiocyanate Hydrochloride Hydrochloride, Fluorescein-5-isothiocyanate 异 异硫氰酸荧光橙红 异硫氰酸荧
CAS Number3326-32-7
PubChem Substance ID18730
EC Number222-042-0
Beilstein Registry Number1407295
MDL NumberMFCD00005063
Reaxys-RN1407295
Merck Number4089
Chemical Name Translation异硫氰酸荧光素酯
LabNetwork Molecule IDLN01308753
InChIInChI=1S/C21H11NO5S/c23-12-2-5-16-18(8-12)26-19-9-13(24)3-6-17(19)21(16)15-4-1-11(22-10-28)7-14(15)20(25)27-21/h1-9,23-24H
Canonical SMILESO=C1OC2(C3=C(OC4=C2C=CC(O)=C4)C=C(O)C=C3)C5=C1C=C(N=C=S)C=C5
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分类

  • {SNA} Biochemicals and Reagents, Fluorescein and Derivatives, Fluorescent Labels, Fluorescent Probes, Labels, Particles and Stains
  • {SNA} E-F, Fluorescein and Derivatives, Fluorescent Labels, Functional Group Reactive Labels, Functional Group Reactive Labels for Flow Cytometry, Functional Group Reactive Labels for Immunoassays, Stains & Dyes, A to Z, Stains and Dyes, 生化试剂, 细胞生物学, 荧光探针,标记,粒子和染色剂, 血液学和组织学
  • {SNA} E-F, Fluorescent Conjugates, Fluorescent Labeled Polymers, Stains & Dyes, A to Z, Stains and Dyes, 生化试剂, 细胞生物学, 荧光探针,标记,粒子和染色剂,

产品应用

  • 生化研究。荧光抗体示踪。病毒和寄生虫等所致疾病的快速诊断。

相关文献及参考

  • Merck: 14,4089
  • Reagent for fluorescent labelling of proteins: Anal. Biochem., 20, 178 (1968).

安全信息

GHS Symbol
WGK Germany3
Hazard Codes Xn
Hazard statements
  • H302+H332
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下,戴呼吸防护。
  • P301+P312+P330
  • P302+P350
  • P302+P352
  • P304+P340+P312
  • P304+P341
  • P305+P351+P338
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P333+P313
  • P337+P313
  • P342+P311
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R42 May cause sensitisation by inhalation 吸入会产生过敏反应
  • R42/43
Storage condition -20°C, protect from light, stored under nitrogen 0-10 0-10°C 2-8°C Moisture Sensitive 储存温度2-8°C 储存温度2-8°C,充氩保存 充氩密封4℃干燥避光保存。

其他信息

  • 存储注意事项:湿度敏感;光敏感
  • Alfa Aesar:异硫氰酸荧光素,isomer1,95% Fluorescein isothiocyanate, isomer 1, 95%(3326-32-7)
  • 上游原料:乙醇 --> 氢氧化钠 --> 盐酸 --> 乙酸乙酯 --> 甲醇 --> 二氯甲烷 --> 乙酸 --> 甲苯 --> 乙酐 --> 钯 --> 氢 --> 间苯二酚 --> 硫氢化钠 --> 九水硫化钠 --> 硫光气 --> 4-硝基邻苯二甲酸
  • 有吸湿性。能与各种抗体蛋白结合,结合后的抗体不丧失与一定抗原结合的特异性,并在碱性溶液中仍有强烈绿色荧光,加酸后析出沉淀,荧光消失,微溶于丙酮、乙醚和石油醚。不溶于水。
  • MOL 文件:3326-32-7.mol
  • Sigma Aldrich:3326-32-7(sigmaaldrich)
  • 用途二:生化研究。荧光抗体示踪。病毒和寄生虫等所致疾病的快速诊断。
  • 异硫氰酸荧光素酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 F0026 异硫氰酸荧光素(异构体I) Fluorescein Isothiocyanate (isomer I) 100MG 318元 2014/06/02 F0026 异硫氰酸荧光素(异构体I) Fluorescein Isothiocyanate (isomer I) 1G 1990元 2010/06/21 119250050 异硫氰酸荧光素酯 Fluorescein isothiocyanate isomer I 90%, pure 5 GR 6887元
  • F:10
  • TCI Shanghai:异硫氰酸荧光素(异构体I) Fluorescein Isothiocyanate (isomer I),>;95.0%(LC)(3326-32-7)
  • Acros Organics:异硫氰酸荧光酯异构体I Fluorescein isothiocyanate isomer I, pure, 90%(3326-32-7)
  • 外观性质:黄色粉末。有吸湿性。能与各种抗体蛋白结合,结合后的抗体不丧失与一定抗原结合的特异性,并在碱性溶液中仍有强烈绿色荧光,加酸后析出沉淀,荧光消失,微溶于丙酮、乙醚和石油醚。不溶于水。熔点:>360 °C
  • 敏感性:Moisture Sensitive
  • 用途一:染色,标记试剂。

系列性分类


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