CAS 3562-84-3 MFCD00078962-Benzbromarone 苯溴马隆 TAO{mole}

Benzbromarone 苯溴马隆

CAS 3562-84-3 MFCD00078962

化学结构图

SMILES: CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1

化学属性

Mol. Formula	C17H12Br2O3
Mol. Weight	424
Melting Point	150.0 to 154.0 deg-C

别名和识别编码

Chemical Name	Benzbromarone
CAS Number	3562-84-3
Synonym	######## (3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran-3-yl)methanone (3,5-Dibromo-4-hydroxyphenyl)(2-ethylbenzofuran-3-yl)ketone (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-3-benzofuranyl)-methanon (3,5-二溴-4-羟基苯基)(2-乙基-3-苯并呋喃基)甲酮 (3,5-二溴-4-羟基苯基)(2-乙基-3-苯并呋喃基)甲酮;3-(3,5-二溴-4-羟基苯甲酰基)-2-乙基苯并呋喃 3,5-Dibromo-4-hydroxyphenyl 2-ethyl-3-benzofuranyl ketone 3,5-dibromo-4-hydroxyphenyl-2-ethylbenzo[b]furan-3-yl ketone 3,5-dibromo-4-hydroxyphenyl2-ethyl-3-benzofuranylketone 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethylbenzofuran; (3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran-3-yl)methanone 3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethyl-benzofura 3-[3,5-DIBROMO-4-HYDROXYBENZOYL]-2-ETHYLBENZOFURAN AL, Benzbromaron Acifugan BENZ BENZBROMARONE BENZBROMARONE, MM(CRM STANDARD)
MDL Number	MFCD00078962
EC Number	222-630-7
PubChem Substance ID	2333
Chemical Name Translation	苯溴马隆
Reaxys-RN	273668
Merck Number	1065
Wiswesser Line Notation	T56 BOJ C2 DVR DQ CE EE
Beilstein Registry Number	0273668
LabNetwork Molecule ID	LN01264882
InChI	InChI=1S/C17H12Br2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3

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品牌质保精细包装现货库存一流品牌服务

产品应用

Benzbromarone is a uricosuric agent used in the treatment of gout and hyperuricemia. Studies show that use of Benzbromarone results in less complications than other uricosuric agent such as Allopurin

安全信息

Hazard Codes Xn

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R22 Harmful if swallowed 吞咽有害

UN Number UN 2811 6.1/PG 3 2811

GHS Symbol

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P203
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P301+P310
P301+P310+P330
P301+P316
P308+P313
P318
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H301 Toxic if swallowed 吞食有毒
H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。

WGK Germany3

Signal word Danger

RTECSOB1804200

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Packing GroupIII

Storage condition 2-8°C 储存温度:2-8°C

Hazard Class6.1

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1230 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 10,232,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 248 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 10,232,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 77 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Kidney, Ureter, Bladder - urine volume decreased
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 6,341,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4120 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 10

TYPE OF TEST

TYPE OF TEST            : TDLo - Lowest publi

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 360 mg/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   SHNSAS Shinryo to Shinyaku.  Medical Consultation and New Remedies.  (Iji
   Shuppan Sha, 1-2-8 Shinkawa, Chuo-Ku, Tokyo 104, Japan)  V.1-    1964-
   Volume(issue)/page/year: 16,1521,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 180 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   SHNSAS Shinryo to Shinyaku.  Medical Consultation and New Remedies.  (Iji
   Shuppan Sha, 1-2-8 Shinkawa, Chuo-Ku, Tokyo 104, Japan)  V.1-    1964-
   Volume(issue)/page/year: 16,1521,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1320 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   SHNSAS Shinryo to Shinyaku.  Medical Consultation and New Remedies.  (Iji
   Shuppan Sha, 1-2-8 Shinkawa, Chuo-Ku, Tokyo 104, Japan)  V.1-    1964-
   Volume(issue)/page/year: 16,1521,1979

其他信息

Sigma Aldrich:3562-84-3(sigmaaldrich)
MOL 文件:3562-84-3.mol
用途一:用于治疗痛风、高尿酸血症