1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester 1-苄基-3-羟基-2(5H)-氧代吡咯-4-羧酸乙酯

CAS 4450-98-0 MFCD00179167

化学结构图

4450-98-0
SMILES: CCOC(=O)C1=C(O)C(=O)N(Cc2ccccc2)C1

化学属性

Mol. FormulaC14H15NO4
Mol. Weight261.27

别名和识别编码

Chemical Name1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester
CAS Number4450-98-0
Alfabeta NameBENZYLHYDROXYOXODIHYDROPYRROLECARBOXYLICACIDETHYLESTER H1452513-----------,
MDL NumberMFCD00179167
Synonym EBPC {LY} EBPC {} {LY} EBPC {} {} {LY} EBPC {} {} {} {LY} EBPC {} {} {} {} {LY} EBPC {} {} {} {} {} {LY} EBPC {} {} {} {} {} {} {LY} EBPC {} {} {} {} {} {} {} {LY} EBPC {} {} {} {} {} {} {} {} {LY} EBPC {} {} {} {} {} {} {} {} {} {LY} EBPC {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} EBPC {} {} {} {} {} {} {} {} {} {} {} {LY} EBPC {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} EBPC {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} EBPC {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} EBPC {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} EBPC {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} EBPC {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} EBPC {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} EBPC {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Chemical Name Translation1-苄基-3-羟基-2(5H)-氧代吡咯-4-羧酸乙酯
InChIKeyIGYRPDIWSYGHMY-UHFFFAOYSA-N
PubChem Substance ID54677973
InChIInChI=1S/C14H15NO4/c1-2-19-14(18)11-9-15(13(17)12(11)16)8-10-6-4-3-5-7-10/h3-7,16H,2,8-9H2,1H3
LabNetwork Molecule IDLN00158793
Canonical SMILESO=C(C1=C(O)C(N(CC2=CC=CC=C2)C1)=O)OCC
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分类

  • Aromatics
  • Inhibitors
  • Heterocycles
  • Pharmaceuticals
  • Pfizer Compounds
  • Intermediates & Fine Chemicals
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, E, Lipids in Cell Signaling, Other Bioactive Lipids, Pfizer Compounds, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, E, Lipids in Cell Signaling, Other Bioactive Lipids, Pfizer Compounds

产品应用

  • A highly specific aldose reductase inhibitor that has been shown to enhance HeLa cell sensitivity to chemotherapeutic drugs.

相关文献及参考

  • Mylari, B.L. et al.: J. Med. Chem., 34, 1011 (1991); Lee, E. et al.: Anti-Cancer Drugs, 13, 859 (2002); Verma, M. et al.: Eur. J. Pharmacol., 584, 213 (2008);

安全信息

Warnings IRRITANT
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
GHS Symbol
WGK Germany3
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P330 Rinse mouth. 漱口
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H318 Causes serious eye damage 严重伤害眼睛
Signal word Danger
Hazard Codes Xn
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
Storage condition room temp

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. E - Bioactive Small Molecules

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