Antimycin A3 抗霉素A3
CAS 522-70-3 MFCD00869273
化学结构图
SMILES: CCCCC1C(=O)OC(C)C(NC(=O)c2cccc(NC=O)c2O)C(=O)OC(C)C1OC(=O)CC(C)C
化学属性
| Mol. Formula | C26H36N2O9 |
|---|---|
| Mol. Weight | 520.64 |
别名和识别编码
| Chemical Name | Antimycin A3 |
|---|---|
| Wiswesser Line Notation | T9OV EOVTJ CMVR BQ CMVH& D1 G4 HOV1Y1&1 I1 |
| Synonym | ANTIMYCIN A(3) Antimycin A3 Blastomycin blastmycin blastomycin |
| CAS Number | 522-70-3 |
| PubChem Substance ID | 245869 |
| InChI | InChI=1S/C26H36N2O9/c1-6-7-9-18-23(37-20(30)12-14(2)3)16(5)36-26(34)21(15(4)35-25(18)33)28-24(32)17-10-8-11-19(22(17)31)27-13-29/h8,10-11,13-16,18,21,23,31H,6-7,9,12H2,1-5H3,(H,27,29)(H,28,32)/t15-,16+,18-,21+,23+/m1/s1 |
| LabNetwork Molecule ID | LN04679863 |
| Chemical Name Translation | 抗霉素A3 |
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相关文献及参考
- [2]. Miyoshi H, et al. Inhibition of electron transport of rat liver mitochondria by unnatural (-)-antimycin A3.
- [3]. Barrow CJ, et al. Antimycins, inhibitors of ATP-citrate lyase, from a Streptomyces sp. J Antibiot (Tokyo). 1997 Sep;50(9):729-33.
- [1]. Ade Arsianti, et al. Synthesis and anticancer activity of polyhydroxylated 18-membered analogue of antimycin A3. Tetrahedron.Volume 68, Issue 13, 1 April 2012, Pages 2884-2891.
- [1]. Ade Arsianti, et al. Synthesis and anticancer activity of polyhydroxylated 18-membered analogue of antimycin A3. Tetrahedron.Volume 68, Issue 13, 1 April 2012, Pages 2884-2891.
- [2]. Miyoshi H, et al. Inhibition of electron transport of rat liver mitochondria by unnatural (-)-antimycin A3.
- [3]. Barrow CJ, et al. Antimycins, inhibitors of ATP-citrate lyase, from a Streptomyces sp. J Antibiot (Tokyo). 1997 Sep;50(9):729-33.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1600 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 10,39,1957
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 10,39,1957
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 900 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,145,1967
