CAS 55661-38-6 MFCD01676942-3-((4-Amino-2-Methylpyrimidin-5-Yl)Methyl)-1-(2-Chloroethyl)-1-Nitrosourea Hydrochloride 3-((4-氨基-2-甲基嘧啶-5-基)甲基)-1-(2-氯乙基)-1-亚硝脲盐酸盐 TAO{mole}

3-((4-Amino-2-Methylpyrimidin-5-Yl)Methyl)-1-(2-Chloroethyl)-1-Nitrosourea Hydrochloride 3-((4-氨基-2-甲基嘧啶-5-基)甲基)-1-(2-氯乙基)-1-亚硝脲盐酸盐

CAS 55661-38-6 MFCD01676942

化学结构图

SMILES: Cl.CC1N=CC(CNC(=O)N(CCCl)N=O)=C(N)N=1

化学属性

Mol. Formula	C9H13ClN6O2·HCl
Mol. Weight	309.15

别名和识别编码

Chemical Name	3-((4-Amino-2-Methylpyrimidin-5-Yl)Methyl)-1-(2-Chloroethyl)-1-Nitrosourea Hydrochloride
Synonym	1-(4-Amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea ACNU N'-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitrosourea hydrochloride Nimustine hydrochloride
MDL Number	MFCD01676942
PubChem Substance ID	87560181
CAS Number	55661-38-6
Reaxys-RN	4220350
Merck Number	6553
Chemical Name Translation	3-((4-氨基-2-甲基嘧啶-5-基)甲基)-1-(2-氯乙基)-1-亚硝脲盐酸盐
Wiswesser Line Notation	T6N CNJ B1 DZ E1MVNNO&2G

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P301+P310+P330
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P405 Store locked up. 上锁保管。
P301+P310
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。

Hazard statements

H301 Toxic if swallowed 吞食有毒

RTECSYR8450000

Signal word Danger

Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes T

Safety Statements

S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Risk Statements

R25 Toxic if swallowed 吞咽有毒

Hazard Class6.1

UN Number 2811

Packing GroupIII

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 60800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 10,884,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 49300 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 83 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   37XLA2 "Current Chemotherapy, Proceedings of the 10th International Congress
   of Chemotherapy, Zurich, 1977," Siegenthaler, W., and R. Luethy, eds., 2
   vols., Washington, DC, American Soc. for Microbiology, 1978
   Volume(issue)/page/year: 2,1233,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 72800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 10,884,1979

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 100 umol/L
REFERENCE :
   INSSDM INSERM Symposium.  (Elsevier Science Pub. Co., Inc., 52 Vanderbilt
   Ave., New York, NY 10017) No.1-    1975-  Volume(issue)/page/year:
   19,49,1981

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Bone marrow
DOSE/DURATION           : 100 umol/L
REFERENCE :
   INSSDM INSERM Symposium.  (Elsevier Science Pub. Co., Inc., 52 Vanderbilt
   Ave., New York, NY 10017) No.1-    1975-  Volume(issue)/page/year

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 3200 ug/L
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   33,455,1985

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Bone marrow
DOSE/DURATION           : 9200 ug/L
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   33,455,1985

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 1 mg/L
REFERENCE :
   AMKUDT Acta Medica Kinki University.  (Kinki Univ. Medical Assoc., 380
   Nishiyama, Sayama-cho, Minami-kawachi-gun, Osaka-fu, Japan)   V.1-    1976-
   Volume(issue)/page/year: 11,57,1986

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 50 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   45,34

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
REFERENCE :
   TJADAB Teratology, The Internation

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 13 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   SKKNAJ Sankyo Kenkyusho Nempo.  Annual Report of Sankyo Research
   Laboratories.  (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku,
   Tokyo 140, Japan)  No.15-    1963-  Volume(issue)/page/year: 29,118,1977

TYPE OF TEST            : TDLo - Lowest pu

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Ro

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 38,553,1988