Betahistine N-甲基-2-吡啶乙胺

CAS 5638-76-6 MFCD00006362

化学结构图

5638-76-6
SMILES: CNCCc1ccccn1

化学属性

Mol. FormulaC8H12N2
Mol. Weight136
Refractive indexn20/D 1.518(lit.)
Boiling Point113-114 °C/30 mmHg(lit.)
Density0.984 g/mL at 25 °C(lit.)

别名和识别编码

Chemical NameN-Methyl-2-pyridineethanamine
MDL NumberMFCD00006362
CAS Number5638-76-6
PubChem Substance ID2366
EC Number227-086-4
Alfabeta NameMETHYLPYRIDINYLETHYLAMINE NN22()------
Chemical Name TranslationN-甲基-2-吡啶乙胺
Synonym (2-(2-Pyridyl)ethyl)methylamine 2-(2-(Methylamino)ethyl)pyridine 2-(2-甲基氨基乙基)吡啶 2-Pyridineethanamine, N-methyl- Aequamen Betahistin AL Betahistin Stada Betahistin ratiopharm Betahistin-ratiopharm Betahistine Betahistine Biphar Betahistine Dihydrobromide Betahistine Dihydrochloride Betahistine Hydrochloride Betahistine Mesylate Betahistine Methanesulfonate Betahistine Methanesulphonate Betaserc Betavert By Vertin By-Vertin Dihydrobromide, Betahistine Dihydrochloride, Betahistine Extovyl Fidium Hydrochloride, Betahistine Lectil Melopat Mersilon Mesylate, Betahistine Methanesulfonate, Betahistine Methanesulphonate, Betahistine {} {PubC
Wiswesser Line NotationT6NJ B2M1
Beilstein Registry Number0112294
LabNetwork Molecule IDLN00179942
InChIInChI=1S/C8H12N2/c1-9-7-5-8-4-2-3-6-10-8/h2-4,6,9H,5,7H2,1H3
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分类

  • {SNA} Building Blocks, C8, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines

相关文献及参考

  • [2]. Gbahou F, et al. Effects of betahistine at histamine H3 receptors: mixed inverse agonism/agonism in vitro and partial inverse agonism in vivo.J Pharmacol Exp Ther. 2010 Sep 1;334(3):945-54.
  • [3]. Tang KT, et al. Betahistine attenuates murine collagen-induced arthritis by suppressing both inflammatory and Th17 cell responses.Int Immunopharmacol. 2016 Oct;39:236-245.
  • [1]. Poyurovsky M, et al. The effect of betahistine, a histamine H1 receptor agonist/H3 antagonist, on olanzapine-induced weight gain in first-episode schizophrenia patients. Int Clin Psychopharmacol. 2005 Mar;20(2):101-3.
  • [1]. Poyurovsky M, et al. The effect of betahistine, a histamine H1 receptor agonist/H3 antagonist, on olanzapine-induced weight gain in first-episode schizophrenia patients. Int Clin Psychopharmacol. 2005 Mar;20(2):101-3.
  • [2]. Gbahou F, et al. Effects of betahistine at histamine H3 receptors: mixed inverse agonism/agonism in vitro and partial inverse agonism

安全信息

GHS Symbol
WGK Germany2
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSUT5552000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Warnings IRRITANT
Hazard Codes Xi
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Safety Statements
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 980 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PBFMAV Problemi na Farmatsiyata.  Problems in Pharmacy.  (Durzhavno
   Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov II, Sofia, Bulgaria) V.1-
      1973-  Volume(issue)/page/year: 13,63,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 320 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PBFMAV Problemi na Farmatsiyata.  Problems in Pharmacy.  (Durzhavno
   Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov II, Sofia, Bulgaria) V.1-
      1973-  Volume(issue)/page/year: 13,63,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6110 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PBFMAV Problemi na Farmatsiyata.  Problems in Pharmacy.  (Durzhavno
   Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov II, Sofia, Bulgaria) V.1-
      1973-  Volume(issue)/page/year: 13,63,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2920 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PBFMAV Problemi na Farmatsiyata.  Problems in Pharmacy.  (Durzhavno
   Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov II, Sofia, Bulgaria) V.1-
      1973-  Volume(issue)/page/year: 13,63,1985

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyridines 吡啶
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Histamine Receptor  (组胺受体)

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