Urea 尿素

CAS 57-13-6 MFCD00008022

化学结构图

57-13-6
SMILES: NC(N)=O

化学属性

Melting Point132-135
TSCAYes
SolubilitySoluble in water, alcohol, methanol, glycerol, benzene, and conc. HCl. Practically insoluble in chloroform, ether
Refractive indexn20/D 1.40
Appearance powder
Density1.335
Mol. FormulaCH4N2O
Mol. Weight60.06

别名和识别编码

Chemical NameUrea
Synonym (NH2)2CO AKOS BBS-00004448 Alphadrate Basodexan Benural 70 CARBIMIDE CO(NH2)2 Carbam Carbamide Carbamide resin Carbonyl diamide Carbonyldiamine Carmol E 927b HARNSTOFF ISOUREA NCI-C02119 Pastaron 20 soft Pseudourea UREA FERTILIZER UREA HYDROCHLORIDE Urea {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Beilstein Registry Number635724
PubChem Substance ID1176
CAS Number57-13-6
EC Number200-315-5
MDL NumberMFCD00008022
Reaxys-RN635724
Merck Number9867
Chemical Name Translation尿素
Wiswesser Line NotationZVZ
LabNetwork Molecule IDLN00195939
InChIInChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)
Canonical SMILESNC(N)=O
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分类

  • {SNA} Bioactive Small Molecules, Biochemicals, Biochemicals an
  • {SNA} Buffers and Reagents, Buffers, Reagents, & Stains, Chaotropic Agents, SDS-PAGE, Urea, Western Blotting, 分子生物学, 变性剂, 生化试剂, 蛋白电泳, 蛋白质组学

产品应用

  • 校准仪器和装置;评价方法;工作标准;质量保证/质量控制

相关文献及参考

  • [2]. Pan M, et al. Urea: a comprehensive review of the clinical literature. Dermatol Online J. 2013 Nov 15;19(11):20392.
  • [3]. Wang H, et al. Urea. Subcell Biochem. 2014;73:7-29.
  • For a procedure for conversion of carboxylic acids to primary amides by heating with urea, see: Org. Synth. Coll., 3, 768 (1955); 4, 513 (1963).
  • For the one-pot conversion of carboxylic acids to nitriles, by heating with urea in the presence of 1.5-2.0 moles of sulfamic acid, see: Chimia, 25, 94 (1971).
  • Reacts with alcohols on prolonged heating to give alkyl carbamates; see, e.g.: Org. Synth. Coll., 1, 140 (1941).
  • Short: II/14a
  • Short: II/19b
  • Widely used in diazotization reactions for the destruction of excess HNO2.
  • [1]. Bennion BJ, et al. The molecular basis for the chemi
  • [1]. Bennion BJ, et al. The molecular basis for the chemical denaturation of proteins by urea. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5142-7.

安全信息

RTECSYR6250000
WGK Germany1
Personal Protective Equipment Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US) Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) Eyeshields, Gloves Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Signal word Warning
GHS Symbol
Safety Statements
  • S37 Wear suitable gloves 戴适当手套;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R38 Irritating to skin 刺激皮肤
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P302+P352
  • P305+P351+P338+P337+P313
  • P332+P313
  • P337+P313
Hazard statements
  • H316 Causes mild skin irritation 会轻微的刺激皮肤
Storage condition 2-8°C 常温和避光条件下保存
Hazard Codes Xn,Xi Xn
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 821 gm/kg/1Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Blood - tumors
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 3(5-6),149,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 394 gm/kg/1Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Blood - tumors
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 3(5-6),149,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 8471 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitari

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APEPA2 Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle
   Pathologie.  (Berlin, Ger.) V.254-263, 1966-69.  For publisher information,
   see NSAPCC.  Volume(issue)/page/year: 257,296,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intratracheal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 567 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
   Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 30(3),43,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5300 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - changes in motor activity (specific assay)
   Behavioral - antipsychotic
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 13,749,1977

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 13 gm/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 265 mmol/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 3,193,1988

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 628 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 203,155,1988

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 50 mmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   25,980,1965

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 16 gm/L/24H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 100 gm/kg/5D (Continuous)
REFERENCE :
   CYTOAN Cytologia.  (Japan Pub. Trading Co. (USA), 1255 Howard St., San
   Francisco, CA 94103) V.1-    1929-  Volume(issue)/page/year: 52,877,1987

TYPE OF TEST            : DNA dama

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraplacental
SPECIES OBSERVED        : Human - woman
DOSE                    : 1600 mg/kg
SEX/DURATION            : female 16 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   1,28,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intrauterine
SPECIES OBSERVED        : Primate - monkey
DOSE                    : 6 gm/kg
SEX/DURATION            : female 18 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 12,372,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraplacental
SPECIES OBSERVED        : Human - woman
DOSE                    : 1400 mg/kg
SEX/DURATION            : female 16 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   OBGNAS Obstetrics and Gynecology.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1953- Volume(issue)/page/year:
   43,765,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraplacental
SPECIES OBSERVED        : Human - woman
DOSE                    : 1600 mg/kg
SEX/DURATION            : female 16 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   BJCPAT British Journal of Clinical Practice.  (Medical News Group, 1 Bedford
   St., London WC2E 9HD, UK)  V.10(10)-    1956- Volume(issue)/page/ye

其他信息

  • Alfa Aesar:尿素,ACS,99.0-100.5% Urea, ACS, 99.0-100.5%(57-13-6)
  • 食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称 允许使用该种添加剂的食品中文名称 添加剂功能 最大允许使用量(g/kg) 最大允许残留量(g/kg) 尿素 食品 食品工业用加工助剂 / 一般应在制成最后成品之前出去,有规定食品中残留量的除外
  • 方法二:其制备方法是将经过净化的氨与二氧化碳按摩尔比2.8~4.5混合进入合成塔,塔内压力为13.8~24.6 MPa,温度为180~200℃,反应物料停留时间为25~40min,得到含过剩氨和氨基甲酸铵的尿素溶液,经减压降温,将分离出氨和氨基甲酸铵后的脲液蒸发到99.5%以上,然后在造粒塔造粒得到尿素成品。
  • 所属类别二:农药中间体: 杀菌剂中间体: 脂肪族类杀菌剂
  • 所属类别三:食品添加剂: 小麦粉、淀粉改质剂: 酵母养料
  • 方法三:尿素中哺乳动物体内蛋白质代谢的最终产物。1922年,在德国实现了用
  • 毒性:GRAS(FDA§184.1923,2000)。 LD 50 14300mg/kg(大鼠,经口)。 可以使用,胶姆糖胶中不超过3%不致有毒(FAO/WHO,2001)。
  • 用途六:酵母食料;胶姆糖组织改进剂。GB2760-90列为加工助剂。用于含醇饮料、明胶制品、葡萄酒、酵母发酵性焙烤制品。
  • 含量分析:准确称取试样约0.5g,溶于10%硫酸液中并定容至l00ml。取该液5.0ml放入长颈燃烧瓶中,加硫酸试液(TS-240)l0ml,小心加热至不再蒸发出气体。小心煮沸10min,冷却后小心加水40ml。再冷却后放入一蒸汽蒸馏器中。加10mol/LNaOH液50ml,在将蒸汽送经混合液的条件下,小心蒸馏1h。将馏出液约50ml收集于盛有40mL 4%(W/V)硼酸液的收集瓶中。加甲基红/甲烯蓝试液(TS-150)0.25ml,用0.1mol/L盐酸滴定。同时作一空白滴定。每毫升0.1 mol/L盐酸相当于尿素(CH 4 N 2 O)3.003mg。
  • 尿素价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 10023218 脲;尿素;碳酰二胺 500g 12.4元 2011/08/23 100232193 脲;尿素;碳酰二胺 25kg/袋 420元 2011/08/23 10023228 脲;尿素;碳酰二胺 500g 11元
  • 鉴别试验:溶解性 易溶于水,溶于乙醇(OT-42)。 硝酸沉淀试验试样0.1g溶于水,加浓硝酸1ml。应有白色结晶性沉淀产生。 呈色反应 于试管中取试
  • 用途三:用于分离氮的氧化物和亚硝酸及色层分析,也用作生物培养剂
  • 方法一:用二氧化碳和氨在高温、高压下合成氨基甲酸铵,经分解、吸收转化后,结晶,分离、干燥而成。
  • Acros Organics:尿素 Urea, DNAse, RNAse and Protease free, for molecular biology, 99.5%(57-13-6)
  • 下游产品:4-苯基-2-羟基嘧啶-5-羧酸 --> 2-羟基嘧啶-5-羧酸乙酯 --> 粘合剂 104T/C --> 霜脲氰 --> 餐具洗洁精 --> 卡巴胆碱 --> 缩二脲 --> 活性黑KN-BN --> 二氯异氰尿酸钠(C3Cl2N3NaO3) --> 5-尿嘧啶甲酸乙酯 --> 颜料黄 65 --> 2,6-二氯-4,8-二哌啶子基嘧啶并[5,4-D]嘧啶 --> 可降解纺织染整整理剂 --> 1,5-二氢嘧啶并[5,4-D]嘧啶-2,4,6,8-(3H,7H)-四酮 --> 直接耐晒黑G --> 氨基模塑料 --> 冲施肥 --> 呋喃西林 --> 烯丙基脲 --> ZR-01 阻燃剂 --> 1-苯基氨基脲 --> 2,4-二氯噻吩并[3,2-D]嘧啶 --> 2,4-二氯噻吩并[3
  • 图谱信息:尿素(57-13-6)质谱(MS) 尿素(57-13-6)红外图谱(IR1) 尿素(57-13-6)核磁图( 1 HNMR) 尿素(57-13-6)Raman光谱 尿素(57-13-6)红外图谱(IR2)

系列性分类


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