4-(2-(2-(Dimethylamino)-2-Oxoethoxy)-2-Oxoethyl)Phenyl 4-Guanidinobenzoate Methanesulfonate 4-(2-(2-(二甲基氨基)-2-氧代乙氧基)-2-氧代乙基)苯基4-胍基苯甲酸酯甲磺酸盐
CAS 59721-29-8 MFCD00941410
化学结构图
SMILES: CN(C)C(=O)COC(=O)CC1C=CC(=CC=1)OC(=O)C1C=CC(=CC=1)NC(N)=N.CS(O)(=O)=O
化学属性
| Mol. Formula | C20H22N4O5·CH3SO3H |
|---|---|
| Mol. Weight | 494.52 |
别名和识别编码
| Chemical Name | 4-(2-(2-(Dimethylamino)-2-Oxoethoxy)-2-Oxoethyl)Phenyl 4-Guanidinobenzoate Methanesulfonate |
|---|---|
| CAS Number | 59721-29-8 |
| Synonym | 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic Acid 2-(Dimethylamino)-2-oxoethyl Ester Methanesulfonate FOY-S 980 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester methanesulfonate; FOY 305; FOY-S 980; Foipan mesylate Foipan Camostat mesylate FOY 305 N,N-Dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)phenylacetate |
| MDL Number | MFCD00941410 |
| Chemical Name Translation | 4-(2-(2-(二甲基氨基)-2-氧代乙氧基)-2-氧代乙基)苯基4-胍基苯甲酸酯甲磺酸盐 |
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分类
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, C-CH, Cholecystokinins, Ion Channels, Monovalent Ion Channels, Neuropeptides, Novartis, Other Sodium Channel Modulators, Peptides and Proteins, Peptides for Cell Biology, Sodium Channel Modulators, Voltage-gated Ion Channels, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience, Cholecystokinins, Ion Channels, Monovalent Ion Channels, Neuropeptides,
产品应用
- Orally active, non-peptide proteolitic enzyme inhibitor with anti-trypsin and anti-plasmin activities, related structurally to gabexate. Protease inhibitor.
相关文献及参考
- [2]. Uno Y. Camostat mesilate therapy for COVID-19 [published online ahead of print, 2020 Apr 29]. Intern Emerg Med. 2020;1‐2.
- [3]. Coote K, et al. Camostat attenuates airway epithelial sodium channel function in vivo through the inhibition of a channel-activating protease. J Pharmacol Exp Ther. 2009;329(2):764‐774.
- [4]. Zhou Y, Vedantham P, Lu K, et al. Protease inhibitors targeting coronavirus and filovirus entry. Antiviral Res. 2015;116:76‐84.
- Coote K, Atherton-Watson HC, Sugar R, Young A, MacKenzie-Beevor A, Gosling M, Bhalay G, et al., Camostat attenuates airway epithelial sodium channel function in vivo through the inhibition of a channel-activating protease. J. Pharmacol. Exp. Ther. 2 , 764-74, (2009)
- Takasugi, S., et al.: Digestion, 24, 36 (1982),
- Tamura, Y., et al.: Biochem. Biophys. Acta, 484, 417 (1977),
- Zhao J, Wang J, Dong L, Shi H, Wang Z, Ding H, Shi H, Lu X., A protease inhibitor against acute stress-induced visce
安全信息
GHS Symbol
- P273 Avoid release to the environment. 避免释放到环境中。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 152 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,590,1985
TYPE OF TEST : LD50 - Let
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,590,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,590,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1320 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R50 Very toxic to aquatic organisms 对水生生物极毒
