CAS 60-51-5 MFCD00053676-O,O-Dimethyl S-(2-(Methylamino)-2-Oxoethyl) Phosphorodithioate O,O-二甲基-S-(N-甲基氨基)-2-氧代乙基)二硫代磷酸酯 TAO{mole}

O,O-Dimethyl S-(2-(Methylamino)-2-Oxoethyl) Phosphorodithioate O,O-二甲基-S-(N-甲基氨基)-2-氧代乙基)二硫代磷酸酯

CAS 60-51-5 MFCD00053676

化学结构图

SMILES: CNC(=O)CSP(=S)(OC)OC

化学属性

Mol. Formula	C5H12NO3PS2
Mol. Weight	229
Density	1.281
Stability	对光敏感
Boiling Point	107°C
Melting Point	52-52.5°C
Flash Point	107 °C
Solubility	Slightly soluble. 2.5 g/100 mL

别名和识别编码

Chemical Name	O,O-Dimethyl S-(2-(Methylamino)-2-Oxoethyl) Phosphorodithioate
CAS Number	60-51-5
PubChem Substance ID	3082
EC Number	200-480-3
Beilstein Registry Number	1785339
MDL Number	MFCD00053676
Synonym	dimethoate Cygon 2E Rogor Phosphorodithioic acid, O,O-dimethyl S-( Rogor L FIP Cekuthoate De-fen Sistemin phosphorodithioic acid o,o-dimethyl s-(2-(methylamino)-2-oxoethyl) ester Racusan C Fosfatox R Perfekthion S ROGOR Fosfotox R Fosfotox R 35 S-Methylcarbamoylmethyl O,O-dimethyl phosphorodithioate O,O-Dimethyl S-(N-methylcarbamoylmethyl) dithiophosphate CHAMP Dimethoate {hazard_co Cygon o,o-dimethyl methylcarbamoylmethyl phosphorodithioate Fostion MM { Rogor P BI 58 Sinoratox {hazard_c Aadimethoal 乐果乳油(40%) 乐果乳化剂90-2 Experimental insecticide 12,880 Lurgo O,O-Dimetil-S-(N-metil-carbamoil-metil)-ditiofosf Dithiophosphate de O,O-dimethyle et de S(-N-methylcarbamoyl-methyle) FOSTION MM(R) Daphene O,O-Dimethyl S-(N-methylcarbamoylmethyl) phosphorodithioate Dimat Systemin (pesticide) O,O dimethyl met Rogor 40 CYGON O,O-二甲基-S-(甲基氨基甲酰甲基)二硫代磷酸酯二硫代磷酸二甲酯(甲基乙酰胺) Phosphorodithioic acid, O,O-dimethyl S-[2-(methylamino)-2 RCRA waste number P044 CL 12880 {uni_ha Phosphorodithio Tara Dimeton {un O,O-DIMETHYL S-(N-METHYLCARBAMOYLMETHYL) PHOSPHORODITHIOATE {h Cygon 400 ENT 24,650 Perfekthion EI-12880 PERFEKTHION(R) Sevigor O,O-Dimethyl
Chemical Name Translation	O,O-二甲基-S-(N-甲基氨基)-2-氧代乙基)二硫代磷酸酯
Merck Number	13,3246
Wiswesser Line Notation	1OPS&O1&S1VM1
InChI	InChI=1S/C5H12NO3PS2/c1-6-5(7)4-12-10(11,8-2)9-3/h4H2,1-3H3,(H,6,7)

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分类

{Chemicalbook} 农药: 杀虫（螨）剂: 有机磷杀虫剂
{SNA} 2000/60/EC, Acaricides, Alpha sort, Alphabetic, Analytical Standards,
{SNA} 2000/60/EC, Acaricides, All alphabetically sorted, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, D, DID - DIN, EPA, Endocrine Disruptors (Draft), Environmental Standards, European Community: ISO, DIN and DL 152, Insecticides, Method and Regulation Specific, Nematicides, Oeko-Tex Standard 100, Organophorous, Organophosphate, Pesticide Class, P

产品应用

校准仪器和装置；评价方法；工作标准；质量保证/质量控制；其他。

安全信息

GHS Symbol

WGK Germany3

Hazard Codes Xn T Xn,T,F

Hazard statements

H351 Suspected of causing cancer 怀疑致癌
H302 Harmful if swallowed 吞食有害
H312 Harmful in contact with skin 皮肤接触有害

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

RTECSTE1750000

Precautionary statements

P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

Signal word Warning

Risk Statements

R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
R45 May cause cancer 可能致癌
R11 Highly flammable 非常易燃
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R36 Irritating to eyes 刺激眼睛

Safety Statements

S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S2 Keep out of the reach of children 避免儿童触及；
S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Storage condition 储存温度2-8℃ 避光阴凉保存 0-6°C

Packing GroupIII

Hazard Class6.1(b)

UN Number UN 2783

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 176 mg/kg/6W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Blood - tumors
REFERENCE :
   ARGEAR Archiv fuer Geschwulstforschung.  (VEB Verlag Volk und Gesundheit
   Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1949-
   Volume(issue)/page/year: 41,311,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 256 mg/kg/4W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Blood - tumors
REFERENCE :
   ARGEAR Archiv fuer Geschwulstforschung.  (VEB Verlag Volk und Gesundheit
   Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1949-
   Volume(issue)/page/year: 41,311,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GUCHAZ Guide to the Chemicals Used in Crop Protection.  (Information Canada,
   171 Slater St., Ottawa, Ont., Canada)  Volume(issue)/page/year: 6,209,1973

TYPE OF TEST            : TD

TYPE OF TEST            : LD10 - Lethal Dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 390 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   8,259,1966

TYPE OF TES

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 33(6),6,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 30,623,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSER

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 ug/plate
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 24,305,1986

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 10 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 172,237,1986

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - hamster
DOSE/DURATION           : 16 mg/kg
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-

TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 75 ppb/96H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(iss

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 44 umol/L
REFERENCE :
   SOGEBZ Soviet Gene

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Fish - not otherwise specified Lymphocyte
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 8,555,1986

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 40 mg/kg
SEX/DURATION            : female 1 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   BIRUAA Biologische Rundschau.  (VEB Gustav Fischer Verlag, Postfach 176,
   Jena DDR-6900, Ger. Dem. Rep.)  V.1-    1963-  Volume(issue)/page/year:
   13,238,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 120 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   BECTA6 Bulletin of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   07094)  V.1-    1966-  Volume(issu

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE                    : 108 mg/kg
SEX/DURATION            : female 14-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 2(6),1283,1979

TYPE OF TEST            :

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 113 mg/kg
SEX/

其他信息

下游产品:马拉硫磷 --> 稻丰散 --> 亚胺硫磷 --> 氟硅酸镁 --> 溴化镁 --> 活性氢氧化镁 --> 过氧化镁 --> 腐殖酸镁
{
用途一:属内吸性触杀杀虫、杀螨剂，能防治多种作物上的广谱害虫和螨类，对卫生害虫特别有效
方法一:O，O-二甲基二硫代磷酸（简称甲基硫代物）的制备通常采用P2S5与CH3OH作用，甲醇适当过量，反应温度55～60℃，为强放热反应，操作时要特别注意安全。反应过程较复杂，同时发生一系列副反应。O，O-二甲基二硫代磷酸的收率和含量75%～80%。采用适当催化剂，在（55±2）℃反应，收率和含量可达90%左右。 O，O-甲基二硫代磷酸盐的制备 O，O-二甲基二硫代磷酸与碳酸钠（铵）或碳酸氢钠在常温下反应，控制终点pH值成盐。 O，O-二甲基-S-（乙酸甲酯）二硫代磷酸酯的制备 O，O-二甲基-S-（乙酸甲酯）二硫代磷酸酯由O，O-二甲基二硫代磷酸钠与氯乙酸甲酯作用制得，原料配比为1:1.7，反应温度55℃，若采用连续化生产工艺，预热温度60～70℃，反应温度（80±5）℃。乐果的合成 O，O-二甲基-S-（乙酸甲酯）二硫代磷酸酯与一甲胺作用，原料配比为1:(1.2～
用途五:乐果是高效广谱具有触杀性和内吸性的杀虫杀螨剂。对多种害虫特别是刺吸口器害虫，具有更高的毒效，杀虫范围广，能防治蚜虫、红蜘蛛、潜叶蝇、蓟马、果实蝇、叶蜂、飞虱、叶蝉、介壳虫。乐果能潜入植物体内保持药效达一星期左右。小鼠口服LD50为156.3mg/kg，经皮LD50为700-1150mg/kg，腹腔注射LD50为184mg/kg。
{Che
用途三
用途四:内吸性杀虫、杀螨剂，具有触杀和一定的胃毒作用，无熏蒸
{Ch
急性毒性:口服-大鼠 L
图谱信息:乐果(60-51-5)红外图谱(IR1) 乐果(60-51-5)核磁图( 13 CNMR) 乐果(60-51-5)
用途四:内吸性杀虫、杀螨剂，具有触杀和一定的胃毒作用，无熏蒸作用。可用于防治多种作物上的刺吸式口器害虫，对蚜虫、螨类及潜叶性害虫高效，用于水稻、棉花、蔬菜、果树等作物。如防治棉蚜、棉红蜘蛛、
上游原料:甲醇 --> 甲苯 --> 碳酸钠 --> 碳酸氢钠 --> 一甲胺 --> 氯乙酸 --> 氧化镁 --> 五硫化二磷 --> 乳化剂 --> 二甲基硫 --> 三氯乙烯 --> 硫酸镁 --> 氯乙酸甲酯 --> 二甲基二硫代磷酸酯 --> 硫代磷酸钠 --> 二甲氧基二硫代磷酸基乙酸甲酯 --> 氯乙酰甲胺
毒性:纯品对大鼠急性经口LD 50 为500～600mg/kg，工业品为320～380mg/kg（94%～96%）。雄大鼠急性经皮LD 50 为650mg/kg。雄野鸭急性经口LD 50 为15mg/kg，雌鸭为40mg/kg (30mg/kg)。鲤鱼LC 50 为40mg/L（48h)。蜜
方法二:工业上生产乐果的方法主要有氯乙酰甲胺法、后胺解法。后一种方法是在氯乙酰甲胺法之后发展起来的，此法副反应少，产品纯度可达90%以上，粗
急性毒性:口服-大鼠 LD50: 60 毫克/公斤; 口服-小鼠 LD50: 60 毫克/公斤
MSDS 信息:乐果(60-51-5).msds
Sigma Aldrich:60-51-5(sigmaaldrich)
灭火剂:砂土、干粉、泡沫
储运特性:库房通风低温干燥; 与食品原料分开储运
方法一:O，O-二甲基二硫代磷酸（简称甲基硫代物）的制备通常采用P2S5与CH3OH作用，甲醇适当过量，反应温度55～60℃，为强放热反应，操作时要特别注意安全。反应过程较复杂，同时发生一系列副反应。O，O-二甲基二硫代磷酸的收率和含量75%～80%。采用适当催化剂，在（55±2）℃反应，收率和含量可达90%左右。 O，O-甲基二硫代磷酸盐的制备 O，O-二甲基二硫代磷酸与碳酸钠（铵）或碳酸氢钠在常温下反应，控制终点pH值成盐。 O，O-二甲基-S-（乙酸甲酯）二硫代磷酸酯的制备 O，O-二甲基-S-（乙酸甲酯）
类别:农药