8-((1H-Imidazol-4-yl)Methylene)-6,8-Dihydro-7H-Thiazolo[5,4-e]Indol-7-One 8-((1H-咪唑-4-基)亚甲基)-6,8-二氢-7H-噻唑并[5,4-e]吲哚-7-酮
CAS 608512-97-6 MFCD06735404
化学结构图
SMILES: O=C1NC2=CC=C3N=CSC3=C2/C/1=C/C1=CNC=N1
化学属性
| Mol. Formula | C13H8N4OS |
|---|---|
| Mol. Weight | 268.29 |
别名和识别编码
| Chemical Name | 8-((1H-Imidazol-4-yl)Methylene)-6,8-Dihydro-7H-Thiazolo[5,4-e]Indol-7-One |
|---|---|
| Synonym | 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one |
| MDL Number | MFCD06735404 |
| CAS Number | 608512-97-6 |
| PubChem Substance ID | 329815469 |
| Chemical Name Translation | 8-((1H-咪唑-4-基)亚甲基)-6,8-二氢-7H-噻唑并[5,4-e]吲哚-7-酮 |
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分类
- Cell Biology, Cell Signaling and Neuroscience, Gene Regulation and Expression, Kinase/Phosphatase Biology, Protein Kinases (PK), RNA-Protein Translation Inhibitors, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
- {SNA} Bioactive Small Molecule Alphabetical Index, Gene Regulation and Expression, I, Kinase/Phosphatase Biology, Protein Kinases (PK), RNA-Protein Translation Inhibitors, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
相关文献及参考
- Ingrand, S., et al., The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation. FEBS Lett. 581 , 4473-4478, (2007) 摘要
- Jammi, N.V., et al., Small molecule inhibitors of the RNA-dependent protein kinase. Biochem. Biophys. Res. Commun. 208 , 50-57, (2003) 摘要
- Shimazawa, M., and Hara, H., Inhibitor of double stranded RNA-dependent protein kinase protects against cell damage induced by ER stress. Neurosci. Lett. 409 , 192-195, (2006) 摘要
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
