CAS 66-28-4 MFCD00046266-Strophanthidin 毒毛旋花子苷元 TAO{mole}

Strophanthidin 毒毛旋花子苷元

CAS 66-28-4 MFCD00046266

化学结构图

SMILES:

化学属性

Mol. Formula	C23H32O6
Mol. Weight	404.50

别名和识别编码

Chemical Name	Strophanthidin
Synonym	19-Oxo-cardogenen-(20:22)-triol-(3-beta,5,14) 3,5,14-Trihydroxy-19-oxocard-20(22)-enolide 3-beta,5,14-Trihydroxy-19-oxo-5-beta-card-20(22)-enolide 3-beta,5,14-Trioxy-19-oxo-carden-(20:22)-olid 3-beta,5,14-Trioxy-19-oxo-digen-(20:22)-olid 3β,5,14-Trihydroxy-19-oxo-5β,20(22)-cardenolide 3β,5,14-Trihydroxy-19-oxo-5β,20(22)-cardenolide Cymarigenen K-Strophanthidin 5-beta-Hydroxy-19-oxodigitoxigenin Antibiotic XS-89 Apocynamarin Card-20(22)-enolide, 3,5,14-trihydroxy-19-oxo-, (3-beta,5-beta)- Convallatoxigenin Corchorgenin Corchorin Corchoside A aglycon Corchsularin Cyanotoxin Cymarigenen Cymarigenin Cynotoxin Erysimupicrone Erysimupikron K-Strophanthidin NSC-86078 Strophanthidin Strophanthidin K Strophanthidine XS-89 k-Strophanthidin k-Strophanthidine 毒毛旋花子甙元
MDL Number	MFCD00046266
CAS Number	66-28-4
PubChem Substance ID	24899714
EC Number	200-626-6
Chemical Name Translation	毒毛旋花子苷元
InChIKey	ODJLBQGVINUMMR-HZXDTFASSA-N
Wiswesser Line Notation	L E5 B666TJ AVH E1 IQ MQ OQ F- DT5OV EHJ
Beilstein Registry Number	0097859

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安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P302+P350
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。

Hazard statements

H330 Fatal if inhaled 吸入致命
H310 Fatal in contact with skin 皮肤接触致命
H300 Fatal if swallowed 吞食致命

RTECSFH5425000

Signal word Danger

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Hazard Codes T+

Safety Statements

S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S22 Do not breathe dust 不要吸入粉尘；

Risk Statements

R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 330 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 8(2),224,1982

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 110 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 185,329,1937

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 240 ug/kg
TOXIC EFFECTS :
   Cardiac - cardiomyopathy including infarction
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 155,251,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 63 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 11,908,1961

TYPE OF TEST            : LDLo -