Ansamitocin P-3 安丝菌素P3
CAS 66584-72-3 MFCD00274586
化学结构图
SMILES:
化学属性
| Mol. Formula | C32H43ClN2O9 |
|---|---|
| Mol. Weight | 635.14 |
别名和识别编码
| Chemical Name | Ansamitocin P-3 |
|---|---|
| MDL Number | MFCD00274586 |
| PubChem Substance ID | 24890696 |
| Synonym | Ansamitocin P-3 from Actinosynnema pretiosum Antibiotic C 15003P3' 3-De(2-(acetylmethylamino)propionyloxy)-3-hydroxymaytansine butyrate Ansamitocin P-3' C 15003 P-3' |
| CAS Number | 66547-09-9 |
| Chemical Name Translation | 安丝菌素P3 |
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资金保障
专业采购外包团队在线服务
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分类
- {SNA} AN-AZ, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, Microtubule Inhibitors
- {SNA} Cytoskeleton and Extracellular Matrix, Microtubule Inhibitors, 细胞信号转导和神经科学, 细胞生物学
相关文献及参考
- [2]. Venghateri JB, et al. Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at thevinblastine site. PLoS One. 2013 Oct 4;8(10):e75182.
- [1]. Kiso T, et al. Screening for microtubule-disrupting antifungal agents by using a mitotic-arrest mutant of Aspergillus nidulans and novel action of phenylalanine derivatives accompanying tubulin loss. Antimicrob Agents Chemother. 2004 May;48(5):1739-48
- [1]. Kiso T, et al. Screening for microtubule-disrupting antifungal agents by using a mitotic-arrest mutant of Aspergillus nidulans and novel action of phenylalanine derivatives accompanying tubulin loss. Antimicrob Agents Chemother. 2004 May;48(5):1739-48
- [2]. Venghateri JB, et al. Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at thevinblastine site. PLoS One. 2013 Oct 4;8(10):e75182.
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H332 Harmful if inhaled 吸入有害
- H315 Causes skin irritation 会刺激皮肤
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H302 Harmful if swallowed 吞食有害
- H319 Causes serious eye irritation 严重刺激眼睛
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 625 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #78-130495
