Xanthohumol 黄腐酚

CAS 6754-58-1 MFCD00210576

化学结构图

6754-58-1
SMILES: COc1cc(O)c(CC=C(C)C)c(O)c1C(=O)/C=C/c1ccc(O)cc1

化学属性

Mol. FormulaC21H22O5
Mol. Weight354
Melting Point158-163

别名和识别编码

Chemical NameXanthohumol
Synonym (E)-1-[2,4-二羟基-6-甲氧基-3-(3-甲基-2-丁烯基)苯基]-3-(4-羟基苯基)丙烯酮 (E)-1-[2,4-二羟基-6-甲氧基-3-(3-甲基-2-丁烯基)苯基]-3-(4-羟基苯基)丙烯酮 2′,4,4′-三羟基-6′-甲氧基-3′-异戊烯基查耳酮 黄腐醇 来源于啤酒花 (Humulus lupulus) 2′,4,4′-三羟基-6′-甲氧基-3′-异戊烯基查耳酮 黄腐醇
MDL NumberMFCD00210576
CAS Number6754-58-1
PubChem Substance ID639665
Chemical Name Translation黄腐酚
Reaxys-RN2226282
InChIKeyORXQGKIUCDPEAJ-YRNVUSSQSA-N
Beilstein Registry Number2226282
InChIInChI=1S/C21H22O5/c1-13(2)4-10-16-18(24)12-19(26-3)20(21(16)25)17(23)11-7-14-5-8-15(22)9-6-14/h4-9,11-12,22,24-25H,10H2,1-3H3/b11-7+
LabNetwork Molecule IDLN00200293
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分类

  • {SNA} Humulus lupulus (Hops), Nutrition Research, Phytochemicals by Plant (Food/Spice/Herb)
  • {SNA} Alphabetical, Analytical Standards, Analytical/Chromatography, Chemical Class, Chromatography, Flavonoids, Flavonoids (Catechins), Humulus, Life Sciences Standards, Natural Compounds,

相关文献及参考

  • [2]. Arnaiz-Cot JJ, et al. Xanthohumol modulates calcium signaling in rat ventricular myocytes: Possible Antiarrhythmic properties. J Pharmacol Exp Ther. 2016 Nov 4. pii: jpet.116.236588
  • [3]. Gallo C, et al. Hop derived flavonoid xanthohumol inhibits endothelial cell functions via AMPK activation. Oncotarget. 2016 Aug 1
  • [4]. Chen PH, et al. The miR-204-3p-targeted IGFBP2 pathway is involved in xanthohumol-induced glioma cell apoptotic death. Neuropharmacology. 2016 Nov;110(Pt A):362-75.
  • [5]. Inokoshi J, et al. Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes. J Antibiot (Tokyo). 2009;62(1):51-54.
  • [6]. Buckwold VE, et al. Antiviral activity of hop constituents against a series of DNA and RNA viruses. Antiviral Res. 2004 Jan;61(1):57-62.
  • [1]. Luzak B, et al. Xanthohumol from hop cones (Humulus lupulus L.) prevents ADP-induced platelet react

安全信息

GHS Symbol
Precautionary statements
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Signal word
Hazard statements
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
WGK Germany3
Personal Protective Equipment Eyeshields, Faceshields, Gloves
Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S22 Do not breathe dust 不要吸入粉尘；
Hazard Codes
Risk Statements
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R50/53
RTECSUD5574117
Storage condition 0-10°C
UN Number
Packing GroupIII

系列性分类

  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Plant (Food/Spice/Herb) - Nutrition Research
  4. Humulus lupulus (Hops) - Phytochemicals by Plant (Food/Spice/Herb)
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Life Sciences Standards - Chromatography
  5. Phytopharma Standards - Life Sciences Standards
  6. Phytopharma Primary Standards - Phytopharma Standards
  1. Medical Research Areas
  2. Metabolism
  3. Acyltransferase  (酰基转移酶)

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