3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE

CAS 676599-90-9 MFCD05865226

化学结构图

676599-90-9
SMILES: CN1C=CC(=C1/C=C/C(=O)NO)C(=O)CC1C=CC=CC=1

化学属性

Mol. FormulaC16H16N2O3
Mol. Weight284.31

别名和识别编码

Chemical NameAPHA Compound 8
Synonym 3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide
CAS Number676599-90-9
PubChem Substance ID329770785
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分类

  • AN-AZ, Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research, Biochemicals and Reagents, Cell Biology, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Epigenetics, Histone Deacetylase Inhibitors, Histone deacetylase, Molecular Biology, Other HDAC Inhibitors
  • {SNA} Bioactive Small Molecules for Epigenetic Research, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Histone Deacetylase Inhibitors, Histone deacetylase, Other HDAC Inhibitors, 分子生物学, 生化试剂, 表观遗传学, 酶、抑制剂和底物

相关文献及参考

  • 1. Mai, A., et al., Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities Bioorg. Med. Chem. Lett. 18 , 2530-2535, (2008)
  • Mai, A., et al., 3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-alkylamides as a new class of synthetic histone deacetylase inhibitors. J. Med. Chem. 46 , 512-524, (2003) 摘要
  • Mai, A., et al., Binding Mode Analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: A new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation. J. Med. Chem. 45 , 1778-1784, (2002)
  • Massa, S., et al., 3-(4-Aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors. J. Med. Chem. 44 , 2069-2072, (2001)

安全信息

Hazard Codes Xn
GHS Symbol
WGK Germany2
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
Signal word Danger
Hazard statements
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H318 Causes serious eye damage 严重伤害眼睛
  • H302 Harmful if swallowed 吞食有害
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Risk Statements
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R22 Harmful if swallowed 吞咽有害
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险

系列性分类


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