CAS 68-89-3 MFCD00020783-Dipyrone 安乃近 TAO{mole}

Dipyrone 安乃近

CAS 68-89-3 MFCD00020783

化学结构图

SMILES: [Na+].CC1=C(C(=O)N(C2C=CC=CC=2)N1C)N(C)CS([O-])(=O)=O

化学属性

Mol. Formula	C13H16N3NaO4S
Mol. Weight	333

别名和识别编码

Chemical Name	Dipyrone
MDL Number	MFCD00020783
PubChem Substance ID	24894234
EC Number	200-694-7
CAS Number	68-89-3
Synonym	安乃近原料药 Noraminopyrine methanesulfonate sodium { Alginodia DIPYRONE Algopyrine Antipyrine, 4-(methylamino)-, monomethosulfate, sodium salt Methylaminophenyldimethylpyrazolone methanesulfonate sodium Farmolisina Metamizol METAMIZOL SODIUM {hazard_ sodium [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1h-pyrazol-4-yl)methylamino]methanesulfonat (antipyrinylmethylamino)methanesulfonicacidsodiumsalt 安乃近 1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethanesulfonatesodium Metapyrin {hazard_co (Antipyrinylmethylamino)methanesulfonic acid sodium salt SODIUM [(1,5-DIMETHYL-3-OXO-2-PHENYL-PYRAZOL-4-YL)-METHY sulpyrine Diprofarn Barone Novaminsulfone (antipyrinylmethylamino)-methanesulfonicacimonosodiumsalt Algocalmin LABOTEST-BB LT00771955 DIPYRONE SODIU Fevonil Fenildimetil-pirazolon-metilaminometansolfonato sodico (antipyrinylmethylamino)-methanesulfonicacisodiumsalt [(2,3-二氢-1,5-二甲基-3-羰基-2-苯基-1H-吡唑-4-基)甲基氨基]甲磺酸一钠盐 dipyron SODIUM DIPYRONE Noramidopyrine methanesu Methampyrone ANALGIN Metamizolo Paralgin Keypyrone METAMIZOLE [(1,5-二甲基-2-苯基-3-氧代-2,3-二氢-1H-吡唑-4-基)甲氨基]甲烷磺酸钠盐 Feverall Bonpyrin 4-Methylamino-1,5-dimethyl-2-phenyl-3-pyrazolone sodium methanesulfonate 安乃近 Dipyrone [(2,3-二氢-1,5-二甲基-3-氧-2-苯基-1H-吡唑-4-基)甲氨基]甲烷磺酸钠 Methylmelubrine 1-phenyl-2,3-dimethylpyrazolone-(5)-4-methylaminome
Chemical Name Translation	安乃近
Wiswesser Line Notation	T5NNVJ A1 BR& D1M1SWQ E1
LabNetwork Molecule ID	LN01287584

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安全信息

RTECSPB1300000

GHS Symbol

Precautionary statements

P342+P311
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

Signal word Danger

Hazard statements

H317 May cause an allergic skin reaction 可能导致皮肤过敏
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难

WGK Germany2

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes Xn

Storage condition 2-8°C 储存温度2-8°C

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R42/43

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 792 mg/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Liver - tumors
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 71,1295,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 536 mg/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Liver - tumors
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 71,1295,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2891 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 24,600,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 21,719,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1625 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 51,183,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JDGRAX Journal of Drug Research.  (National Organization for Drug Research
   and Control, POB 29, Cairo, Egypt)  V.2-    1969-  Vol

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 5 mg/disc
REFERENCE :
   JNUDAT Journal of Nihon University School of Dentistry.  (Nihon University
   School of Dentistry, 1-8-13 Surugadai, Kanda, Chiyoda-ku, Tokyo, 101, Japan)
    V.1-    1958-  Volume(issue)/page/year: 34,183,1992

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   AMONDS Applied Methods in Oncology.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1978- Volume(issue)/page/year:
   3,253,1980

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 15600 ug/kg
REFERENCE :
   CARYAB Caryologia.  (Via G. LaPira 4, 50121 Florence, Italy)  V.1-    1948-
   Volume(issue)/page/year: 36,385,1983

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TE

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 250 mg/L
REFERENCE :
   SOGEBZ Soviet Genetics.  English translation of GNKAA5.  (Plenum Pub. Corp.,
   233 Spring St., New York, NY 10013)  V.2-    1966- Volume(issue)/page/year:
   11,528,1975

TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 1150 mg/kg
REFERENCE :
   EJGCA9 Egyptian Journal of Genetics and Cytology.  (Egyptian Soc. of
   Genetics, c/o Alexandria Univ., Faculty of Agriculture, Dept. of Genetics,
   Alexandria, Egypt)  V.1-    1972-  Volume(issue)/page/year: 11,105,1982

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 750 mg/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   JMTHBU Journal of the Medical Association of Thailand.  (Businesss Mgr.,
   Dept. of Microbiology, Faculty of Medicine, Siriraj Hospital, Bangkok 7,
   Thailand)  V.1-    1918-  Volume(issue)/page/year: 53,550,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 30 mg/kg
SEX/DURATION            : lactating female 41 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - other neonatal measures or effects
REFERENCE :
   HUTODJ Human Toxicology.  (Macmillan Press Ltd., Houndmills, Basingstoke,
   Hants., RG 21 2XS, UK) V.1-    1981-  Volume(issue)/page/year: 3,505,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1 gm/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   JMTHBU Journal of the Medical Association of Thailand.  (Businesss Mgr.,
   Dept. of Microbiology, Faculty of Medicine, Siriraj Hospital, Bangkok 7,
   Thailand)  V.1-    1918-  Volume(issue)/page/year: 53,550,1973

其他信息

储运特性:库房通风低温干燥
上游原料:亚硫酸氢钠
毒性分级:中毒
可燃性危险特性:可燃;燃烧产生有毒氮氧化物,硫氧化物和氧化钠烟雾
MOL 文件:68-89-3.mol
Sigma Aldrich:68-89-3(sigmaaldrich)
灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
用途一:有解毒、镇痛、抗风湿作用。主要用于退热，也用于急性关节炎、风湿性痛、肌肉痛、头痛等。
急性毒性:口服-大鼠 LD50: 3000 毫克/公斤;口服-小鼠LD50: 2891 毫克/公斤
安乃近的副作用:1，过敏、虚脱、白细胞减少、血小板减少，严重的可引起再生障碍性贫血. 2，肾毒性、胃肠道出血、严重皮疹，致死性粒细胞缺乏为其最严重副作用。
药品说明书:【别名】安乃近 ,诺瓦经;罗瓦而精 ,罗瓦尔精，安替比林甲胺甲烷【外文名】Metamizole Sodium, Analgin, Bonpyrin, Dipyron, Noramidopyrine, NOVALGIN 【性状】本品为白色或黄白色的结晶或结晶性粉末，无臭，味微苦，易溶于水。【作用】：为氨基比林的衍生物，具有较显著的解热作用及较强的镇痛作用，解热作用为氨基比林的3倍，镇痛作用与氨基比林相似。【体内过程】口服易吸收，主要经肝脏代谢，肾脏排泄。【适应症】主要用于退热，亦用于急性关节炎、头痛、风湿性神经痛、牙痛、肌肉痛等。【用法用量】口服或滴鼻，口服成人每次0.5g,一日3次，儿童每次8-10mg/kg，必要时重复；滴鼻剂5岁以下每次每侧鼻孔1-2滴，必要时重复一次，5岁以上适当加量。【注意事项】1、严格控制用量，以防虚脱。2、肌肉注射可致局部肌肉萎缩及糜烂，现已不用。 3、对吡喹酮类药有过敏史者禁用。 4、不宜长期使用，注意复查粒细胞。【规格】片剂，每片0.25g，0.5g；针剂，每支0.25g/1ml，0.5g/2ml；滴剂10-20%溶液
类别:有毒物品