Tromethamine 三羟甲基氨基甲烷

CAS 77-86-1 MFCD00004679

化学结构图

77-86-1
SMILES: NC(CO)(CO)CO

化学属性

Mol. FormulaC4H11NO3
Mol. Weight121.14
Boiling Point219-220
Melting Point167-172°C
Density1.353
TSCAYes
Solubility550 G/L (25 ºC)
Flash Point732°C
Appearance 白色结晶或粉末。熔点171-172℃ ,沸点219-220℃ /1.3kPa,溶于乙醇和水,微溶于乙酸乙酯、苯、不溶于乙醚、四氯化碳,对铜、铝有腐蚀作用,有刺激性。 crystalline
Stability对湿度敏感

别名和识别编码

Chemical NameTris(hydroxymethyl)aminomethane
CAS Number77-86-1
Alfabeta NameAMINOHYDROXYMETHYLPROPANEDIOL 2213()-----,
MDL NumberMFCD00004679
Synonym 2-AMINO-2-(HYDROXYMETHYL)PROPANE-1,3-DIOL 2-Amino-2-(hydroxymethyl)-1,3-propanediol 2-amino-2-hydroxymethylpropanediol 2-氨基-2 2-氨基-2-(羟甲基) 2-氨基-2-(羟甲基)-1,3-丙二醇 2-氨基-2-(羧甲基)- 8VTE 1L AMINOMETHYLIDINE TRIMETHANOL Aminotris(hydroxymethyl)methane Methylamin Pehanorm SIGMA 7-9(R) THAM TRISAMINE Tri(hydroxymethyl)aminomethane Trimethylolaminomethane Tris 缓血酸胺 Tris (buffering agent) Tris Buffer Tris bu Tris(hydroxymethyl)aminomethane Tris, free base Tris-(hydroxymethy Tris-Magnesium(II)-Potassium Chloride Buffer Tris-Mg(II)-KCl Buffer Trisamine Trizma Trometamol {} {} {} {} { {} {} {} {
PubChem Substance ID6503
EC Number201-064-4
Beilstein Registry Number741883
Reaxys-RN741883
Merck Number9772
Chemical Name Translation三羟甲基氨基甲烷
Wiswesser Line NotationQ1XZ1Q1Q
LabNetwork Molecule IDLN00335089
InChIInChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
Canonical SMILESOCC(CO)(N)CO
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分类

  • {SNA} Analytical Reagents, Analytical/Chromatography, Biochemicals and Reagents, Biological Buffers, Buffers & Reagents, Buffers A to Z, Chromatography Reagents & Solvents, Good’s Buffers, HPLC,
  • Biochemicals and Reagents, Biological Buffers, Buffers, Buffers / Buffer salts, Buffers A to Z, Buffers and Reagents, Buffers, Reagents, & Stains, Core Bioreagents,
  • {SNA} Alphabetical, BioUltra Buffers, Biochemicals and Reagents, Biological Buffers, Luminescent Compounds/Detection, Solvents, Buffers and Reagents for Luminescence, Zwitterionic
  • {S
  • {SNA} Analytical Standards,
  • {SNA} BioPerformance Certified Buffers,
  • {SNA}

产品应用

  • 生物缓冲剂,缓冲范围pH7.0-9.0。酸性气体吸收剂。酸量滴定法基准物质。电流滴定法测定蛋白质中的巯基。纸上电泳分离血清蛋白。淀粉平板电泳分离毒素。

相关文献及参考

  • Merck: 14,9772 Beilstein: 4,IV,1903
  • Short: IV/4
  • Santoni, V., et al. Electrophoresis 21 , 1054, (2000) 摘要
  • Merck: 14,9772
  • Short: III/5a
  • Widely used biological buffer.
  • Short: IV/8A
  • Merck 14 ,9772

安全信息

Warnings IRRITANT
GHS Symbol
WGK Germany2
Hazard Codes Xi Xi,N,C,F+,F
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves Eyeshields, Gloves
RTECSTY2900000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S18 Handle and open container with care 小心搬运和开启容器;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S37 Wear suitable gloves 戴适当手套;
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 2-8°C Hygroscopic 密封保存。
Packing GroupII
Hazard Class3
UN Number
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1210 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABMGAJ Acta Biologica et Medica Germanica.  (Berlin, Ger. Dem. Rep.) V.1-41,
   1958-82.  For publisher information, see BBIADT. Volume(issue)/page/year:
   17,217,1966

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Behavioral - coma
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 22,315,1940

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   110,653,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,419,1990

其他信息

  • 上游原料:甲醇 --> 碳酸钾 --> 钯 --> 多聚甲醛 --> 硝基甲烷 --> 三(羟甲基)硝基甲烷
  • 用途一:主要用于医药中间体
  • {Chem
  • 用途四:用作有机合成工业的脱水剂、缩合剂及生产香兰素、兔耳草醛、消炎止痛药物、阳离子交换树脂的催化剂。可作聚丙烯腈的溶剂。染织工业用作媒染剂、丝光剂、上浆剂。纺织工业用作生产棉条桶、梭子等材料的原料(棉纤维的助溶剂),可提高纤维的黏合力。染料工业用作冰染染料显色盐的稳定剂,用于生产活性染料和阳离子染料。用作石油净化剂和活性炭的活化剂。用于浸渍木材使具有防腐性和阻燃性。用作硬纸板和布制品的阻燃剂。用于电镀。用作电焊条的
  • 毒性分级:中毒
  • 海关编码:29221980
  • Alfa Aesar:三(羟甲基)氨基甲烷,ACS,99.8-100.1%(Assay,driedbasis) Tris(hyd
  • 图谱信息:三羟甲基氨基甲烷(77-86-1)质谱(MS) 三羟甲基氨基甲烷(77-86-1)红外图谱(IR1) 三羟甲基氨基甲烷(77-86-1)核磁图( 13 CNMR) 三羟甲基氨基甲烷(77-86-1)红外图谱(IR2)
  • 方法一:盐酸法将一定量的氧化加入盛有一定量盐酸的反应器中遗反应,生成氯化锌溶液。当溶液的为3.5~4时,经静置沉淀,将清送去第一次提纯,加入氯化钡、高酸钾、氯酸钾等进行净化以除去碲根、铁等杂质。再经静置沉降,把液送去第二次提纯,加人锌粉以阱铅、镉等重金属,经过滤,把滤沼入石墨坡板蒸发器进行浓缩,浓45%的稀氯化锌溶液从高处向低处与火向并流,出口处浓度达98%以上析出结晶,经粉碎,制得氯化锌品。其 ZnO+2HCl→ZnC12+H2O
  • {Chemica
  • 用途一:用作脱水剂、催化剂、媒染剂、上浆剂、增重剂、防腐剂,还用于电镀、染料、医药、农药等工业
  • 用途二:用作分析试剂、石油净化剂和有机合成脱水剂
  • {Chemi
  • 下游产品:三氟氯乙烯 --> C.I. 色基45 --> 6-叔丁基间甲酚 --> 3-甲基-1H-吡唑并[3,4-B]吡啶 --> 2-氨基-3-氰基吡啶 --> 4-己基间苯二酚 --> 2-丙酰呋喃,97% --> 2-氯-5-氯甲基噻吩 --> 4-癸基苯胺 --> 1-氯戊烷 --> 聚砜阴离子交换膜 --> 聚苯乙烯型聚乙烯均相阴离子交换膜 --> 1-氯丙烷 --> 碱性品红 --> 氯代异丁烷 --> 4-正丁基苯胺 --> 强碱性苯乙烯系阴离子交换树脂 --> 2-氨基烟酸 --> 5-甲氧基-2-甲基吲哚 --> 2-氨基-5-氯-2'-氟二苯甲酮 --> 4-氯甲基-3,5-二甲基异噁唑 --> 1H-吡唑并[3,4-B]吡啶 --> 依昔苯酮 --> 6-甲氧基-4-甲基喹啉 --> 邻甲酚酞 --> 2-(1-环己烯基)环己酮 --> 酚红 --> 2',4'-二羟基苯己酮 --> 1,1-二氯乙烷 --> 3-氨基-2-萘甲酸 --> 甲酚红
  • 用途三
  • 氯化锌价格(试剂级):更新日期 产品编号 产品名称 包装 价
  • 防护措施:氯化锌毒性很强,能剧烈刺激及烧灼皮肤和粘膜,长期与本品蒸气接触时发生变应性皮炎。吸入氯化锌烟雾经5~30min后能引起阵发性咳嗽、恶心。对上呼吸道、气管、支气管粘膜有损害。 美国对氯化锌烟雾规定最高容许浓度为1mg/m3。 生产人员工作时要穿工作服,戴防护眼镜、防毒口罩、乳胶手套,以保护皮肤、眼睛、呼吸器官。车间通风要良好,下班后要洗热水淋浴。
  • Alfa Aesar:无水氯化锌,98+% Zinc chloride, anhydrous, 98+%(7646-85-7)
  • 氯化锌价格(试剂级):更新日期 产品编号 产
  • Sigma Aldrich:7646-85-7(sigmaaldrich)
  • {Ch
  • F:3
  • color:white
  • MOL 文件:7646-85-7.mol
  • 敏感性:Hygroscopic
  • 蒸气压:1 mm Hg

系列性分类


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