Castanospermine 栗精胺

CAS 79831-76-8 MFCD00017555

化学结构图

79831-76-8
SMILES: O[C@H]1CN2CC[C@H](O)[C@@H]2[C@@H](O)[C@@H]1O

化学属性

Mol. FormulaC8
Mol. Weight189
Melting Point213-217 °C (lit.)

别名和识别编码

Chemical NameCastanospermine
CAS Number79831-76-8
Synonym (1S,6S,7R,8R,8aR)-Octahydro-1,6,7,8-indolizinetetrol 栗精胺 (1S,6S,7R,8R,8aR)-1,6,7,8-四羟基八氢吲哚里西定 (1S,6S,7R,8R,8aR)-八氢-1,6,7,8-吲嗪四醇 1,6,7,8-四羟基八氢吲嗪 栗树精胺 (1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyoctahydroindolizidine (1S,6S,7R,8R,8aR)-Octahydro-1,6,7,8-indolizinetetrol 栗树精胺 (1S,6S,7R,8R,8aR)-八氢-1,6,7,8-吲嗪四醇 (+)-Castanospermine (1S,6S,7R,8R,8aR)-1,6,7,8-四羟基八氢吲哚里西定 1,6,7,8-四羟基八氢吲嗪
MDL NumberMFCD00017555
PubChem Substance ID24877905
Beilstein Registry Number3588654
Chemical Name Translation栗精胺
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分类

  • {SNA} Biochemicals and Reagents, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Glucosidase, alpha-, Glycobiology, Inhibitors, Inhibitors and Substrates, Post-Translational Modification, Proteomics
  • {SNA} Asymmetric Synthesis, Chemical Synthesis,

产品应用

  • Castanospermine is a plant alkaloid shown to be a potent inhibitor of lysosomal a-or beta- glucosidase. It also inhibits mammalian glucosidase 1 and beta-mannosidase from sweet almonds and fungal be

相关文献及参考

  • [2]. Eisaku Tsujii et al. Nectrisine Is a Potent Inhibitor of a-Glucosidases, Demonstrating
  • [3]. Pili R et al. The alpha-glucosidase I inhibitor castanospermine alters endothelial cell glycosylation, preventsangiogenesis, and inhibits tumor growth. Cancer Res. 1995 Jul 1;55(13):2920-6.
  • Activities Similarly at Enzyme and Cellular Levels. Biochemical and Biophysical Research Communications 220, 459-466 (1996)
  • Activities Similarly at Enzyme and Cellular Levels. Biochemical and Biophysical Research Communications 220, 459-466 (1996)
  • Arch. Biochem. Biophys., 221, 593 (1983),
  • Clin. Biochem., 17, 3 (1984),
  • J. Biol. Chem., 260, 15873-15879 (1985),
  • Merck 14 ,1896
  • Trends Bio. Sci., 9, 32, (1984),
  • [1]. Bryan G, Anthony C et al. The structural basis of the inhibition of human glycosidases by
  • [1]. Bryan G, Anthony C et al. The structural basis of the inhibition of human glycosidases by
  • [2]. Eisaku Tsujii e

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
Hazard Codes Xn
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害

系列性分类

  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Chemical Classification - Nutrition Research
  4. Plant Extracts - Phytochemicals by Chemical Classification
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. D to K - Enzyme Inhibitors by Enzyme
  7. Glucosidase, alpha- - D to K
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. D to K - Enzyme Inhibitors by Enzyme
  7. Glucosidase, alpha- - D to K
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Building Blocks 手性分子砌块
  4. Heterocyclic Building Blocks - Chiral Building Blocks
  5. Indoles - Heterocyclic Building Blocks
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Type - Enzyme Inhibitors
  6. Substrate Analogs - Enzyme Inhibitors by Type
  1. Life Science 生命科学
  2. Proteomics 蛋白质组学
  3. Post-Translational Modification - Proteomics
  4. Glycobiology - Post-Translational Modification
  5. Inhibitors and Substrates - Glycobiology
  6. Inhibitors - Inhibitors and Substrates
  1. Medical Research Areas
  2. Metabolism
  3. Glucosidase  (葡萄糖苷酶)

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