CAS 90-52-8 MFCD00672902-8-Amino-6-Methoxyquinoline 8-氨基-6-甲氧基喹啉 TAO{mole}

8-Amino-6-Methoxyquinoline 8-氨基-6-甲氧基喹啉

CAS 90-52-8 MFCD00672902

化学结构图

SMILES: COc1cc(N)c2ncccc2c1

化学属性

Mol. Formula	C10H10N2O
Mol. Weight	174.20
Appearance	白色结晶。熔点41℃，沸点137-138℃（133Pa）。
Melting Point	41°C
Boiling Point	361.8±27.0°C at 760 mmHg

别名和识别编码

Chemical Name	8-Amino-6-Methoxyquinoline
Alfabeta Name	METHOXYQUINOLINAMINE 68---
MDL Number	MFCD00672902
Chemical Name Translation	8-氨基-6-甲氧基喹啉
Synonym	8-Amino-6-methoxyquinoline {LY} 8-Amino-6-methoxyquinoline {} {LY} 8-Amino-6-methoxyquinoline {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {} {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {} {} {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {} {} {} {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {} {} {} {} {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {} {} {} {} {} {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {} {} {} {} {} {} {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 8-Amino-6-methoxyquinoline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 8-Amino-6-meth
CAS Number	90-52-8
EC Number	202-001-3
Wiswesser Line Notation	T66 BNJ HO1 JZ
Beilstein Registry Number	0133397
InChIKey	YGGTVPCTAKYCSQ-UHFFFAOYSA-N
LabNetwork Molecule ID	LN00159054
PubChem Substance ID	7023
InChI	InChI=1S/C10H10N2O/c1-13-8-5-7-3-2-4-12-10(7)9(11)6-8/h2-6H,11H2,1H3
Canonical SMILES	COC1=CC(N)=C2N=CC=CC2=C1

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安全信息

Warnings IRRITANT

RTECSVA9635000

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD691-490

Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

GHS Symbol

其他信息

用途一:抗疟类药物磷酸伯氨喹啉、戊喹、扑疟喹的中间体。
方法一:6-甲氧基-8-硝基喹啉在盐酸介质中用铁粉还原、再用液碱中和而得。将盐酸投入搪玻璃反应锅，升温到50℃，投入6-甲氧基-8-硝基喹啉、铁粉。在65-70℃于3.5h内全部加完，保温2h，冷却，过滤得粗品8-氨基-6-甲氧基喹啉盐酸盐。再经盐析精制，用稀碱中和至pH7，析出8-氨基-6-甲氧基喹啉，过滤得粗品，用甲苯精制，得8-氨基-6-甲氧基喹啉。收率65%。产品规格：含量≥65%。原料消耗定额：6-甲氧基-8-硝基喹啉（94%）1765kg/t、盐酸（37%）10479kg/t、铁屑（工业品）2519kg/t。
MOL 文件:90-52-8.mol
上游原料:乙醇 --> 氢氧化钠 --> 盐酸 --> 乙酸乙酯 --> 硫酸 --> 石油醚 --> 三氯甲烷 --> 氨 --> 氯化亚锡 --> 甘油 --> 硝基苯 --> 搪玻璃反应锅 --> 铁屑 --> 冰染重氮组分 1 --> 6-甲氧基-8-硝基喹啉 --> 奎啉盐酸盐