分类

• {SA} 3.2.x.x Glycosidases, 3.x.x.x Hydrolases, Application Index, Biochemicals and Reagents, Carbohydrate Hydrolysis,
• 3.2.x.x G
• {SNA} 3.2.x.x Glycosidases, 3.x.x.x Hydrolases, Application Index, Biochemicals and Reagents, Carbohydrate Hydrolysis, Carbohydrate and PTM Analysis, Carbohydrate hydrolysis & PTM analysis,

产品应用

• A hydrolytic enzyme that removes sialic acid from mucoproteins

相关文献及参考

• Arabkhari, M., et al., Desialylation Of Insulin Receptors And IGF-1 Receptors By Neuraminidase-1 Controls The Net Proliferative Response Of L6 Myoblasts To Insulin. Glia 20 , 603-16, (2010) 摘要
• Dougan, D.A., et al, Effects of substitutions in the binding surface of an antibody on antigen affinity Protein Eng. 111(1) , 65–74, (1998)
• Murrell, M.T., et al, A single amino acid alteration in the human parainfluenza virus type 3 hemagglutinin-neuraminidase glycoprotein confers resistance to the inhibitory effects of zanamivir on receptor binding and neuraminidase activity. J. Virol. 75(14) , 6310-6320, (2001)
• Murrell, M., et al, Mutations in Human Parainfluenza Virus Type 3 Hemagglutinin-Neuraminidase Causing Increased Receptor Binding Activity and Resistance to the Transition State Sialic Acid Analog 4-GU-DANA (Zanamivir) J. Virol. 77(1) , 309-317, (2003)
• Porotto, M., et al, Triggering of Human Parainfluenza Virus 3 Fusion Protein (F) by the Hemagglutinin-Neuraminidase (HN) Protein: an HN Mutation Diminishes the Rate of F Activation and Fusion J. Virol. 77(6) , 3647-3654, (2003)
• Zimmer, G., et al, A Chimeric Respiratory Syncytial Virus Fusion Protein Functionally Replaces the F and HN Glycoproteins in Recombinant Sendai Virus J. Virol. 79(16) , 10467–10477, (2005)
• Cassidy, J.T., et al. J. Biol. Chem. 240 , 3501, (1965)

安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 4000 iu/kg
SEX/DURATION            : female 4-6 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   NMJOAA Nagoya Medical Journal.  (Nagoya City Univ. Medical School, Kawasumi,
   Mizuho-cho, Mizuho-ku, Nagoya 467, Japan)  V.1-    1953-
   Volume(issue)/page/year: 22,135,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2000 iu/kg
SEX/DURATION            : female 4 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   NMJOAA Nagoya Medical Journal.  (Nagoya City Univ. Medical School, Kawasumi,
   Mizuho-cho, Mizuho-ku, Nagoya 467, Japan)  V.1-    1953-
   Volume(issue)/page/year: 22,135,1977

其他信息

• Neuraminidase (sialidase) removes N-acetyl neuraminic acid (sialic acid) from a variety of glycoproteins. The enzyme has an optimum pH of 5.0-5.1. Little or no activity is observed at pH 4.0 or above pH 8.0.