Azd-8055 [5-[2,4-二((3S)-3-甲基吗啉-4-基)吡啶并[2,3-D]嘧啶-7-基]-2-甲氧基苯基]甲醇
CAS 1009298-09-2 MFCD109298092
化学结构图
SMILES: COc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCOC[C@@H]4C)nc3n2)cc1CO
化学属性
| Mol. Weight | 465.54 |
|---|---|
| Mol. Formula | C25H31N5O4 |
| Density | 1.2 |
| Boiling Point | 694.3 |
| Melting Point | 204-208 |
| Appearance | Yellow solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| CAS Number | 1009298-09-2 |
|---|---|
| Chemical Name | Azd-8055 |
| Synonym | ######## (5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol AZD8055 AZD8055; AZD-8055; AZD 8055. |
| Chemical Name Translation | [5-[2,4-二((3S)-3-甲基吗啉-4-基)吡啶并[2,3-D]嘧啶-7-基]-2-甲氧基苯基]甲醇 |
| PubChem Substance ID | 25262965 |
| InChI | InChI=1S/C25H31N5O4/c1-16-14-33-10-8-29(16)24-20-5-6-21(18-4-7-22(32-3)19(12-18)13-31)26-23(20)27-25(28-24)30-9-11-34-15-17(30)2/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17-/m0/s1 |
| LabNetwork Molecule ID | LN00202369 |
| Formula | C25H31N5O4 |
| IUPAC Name | (5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol. |
| InChIKey | KVLFRAWTRWDEDF-IRXDYDNUSA-N |
| Canonical SMILES | OCC1=CC(C2=NC3=NC(N4[C@@H](C)COCC4)=NC(N5[C@@H](C)COCC5)=C3C=C2)=CC=C1OC |
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分类
- Aromatics
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Protein Kinase Inhibitors and Activators
产品应用
- AZD-8055 is an inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor AZD8055 inhibits the serine/threonine kinase activity of mTOR, resulting in decreased expression of mRNAs necessary for cell cycle progression, which may induce cell cycle arrest and tumor cell apoptosis. mTOR phosphorylates transcription factors, such as S6K1 and 4E-BP1, which stimulate protein synthesis and regulate cell growth, proliferation, motility, and survival.
相关文献及参考
- Chresta, C.M. et al.: Cancer Res., 70, 288 (2010); Sini, P. et al. Autophagy., 6 (2010); Marshall, G. et al.: Biochem. Soc. Trans., 39, 456 (2011);
安全信息
GHS Symbol
