Rel-N-(5-(3,5-Dimethoxyphenethyl)-1H-Pyrazol-3-Yl)-4-((3R,5S)-3,5-Dimethylpiperazin-1-Yl)Benzamide rel-N-(5-(3,5-二甲氧基苯乙基)-1H-吡唑-3-基)-4-((3R,5S)-3,5-二甲基哌嗪-1-基)苯甲酰胺
CAS 1035270-39-3 MFCD135270393
化学结构图
SMILES:
化学属性
| Mol. Weight | 464 |
|---|---|
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
| Mol. Formula | C26H33N5O3 |
别名和识别编码
| Chemical Name Translation | rel-N-(5-(3,5-二甲氧基苯乙基)-1H-吡唑-3-基)-4-((3R,5S)-3,5-二甲基哌嗪-1-基)苯甲酰胺 |
|---|---|
| Chemical Name | Rel-N-(5-(3,5-Dimethoxyphenethyl)-1H-Pyrazol-3-Yl)-4-((3R,5S)-3,5-Dimethylpiperazin-1-Yl)Benzamide |
| LabNetwork Molecule ID | LN02125708 |
| Formula | C26H33N5O3 |
| Synonym | AZD4547; AZD-4547; AZD 4547. |
| IUPAC Name | N-(5-(3,5-dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzamide |
| InChIKey | VRQMAABPASPXMW-HDICACEKSA-N |
| InChI | InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+ |
| MDL Number | N/A |
| CAS Number | 1035270-39-3 |
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产品应用
- AZD4547 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor AZD4547 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways, and, so, the inhibition of tumor cell proliferation and tumor cell death. FGFR, up-regulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cellular proliferation, differentiation and survival.
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