CAS 10405-02-4 MFCD10405024-Trospium Chloride 曲司氯铵 TAO{mole}

Trospium Chloride 曲司氯铵

CAS 10405-02-4 MFCD10405024

化学结构图

SMILES: [Cl-].OC(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]12CCCC1)(c1ccccc1)c1ccccc1

化学属性

Mol. Weight	428
Mol. Formula	C25H30ClNO3

别名和识别编码

CAS Number	10405-02-4
Chemical Name	Trospium Chloride
Synonym	Spasmex Sanctura Keptan Azoniaspiro(3-alpha-benziloyloxy-nortropan-8,1'-pyrrolidine)-chloride Spasmo 3 AS Xvii 8-alpha-Benziloyloxy-6,10-ethano-5-azoniaspiro(4.5)decane chloride Azoniaspiro Compound XVII Azoniaspiro (1?,3?,5?)-3-[(2-Hydroxy-2,2-diphenylacetyl)oxy]-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-pyrrolidinium] Chloride 曲司氯胺 Trospium chloride Relaspium
EC Number	233-875-4
InChIKey	RVCSYOQWLPPAOA-QKYUOBHYSA-M
Wiswesser Line Notation	T56 A AKTJ GQ A-& AT5KTJ &G
Chemical Name Translation	曲司氯铵
MDL Number	N/A

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产品应用

Tropine derivative with anticholinergic activity. Antispasmodic; used in treatment of urinary incontinence.

安全信息

RTECSWH1424000

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 203 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 8,199,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 97700 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 8,

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15500 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 8,199,1974

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)

GHS Symbol

UN Number 3077

Hazard Codes 9

Signal word Warning

WGK Germany3

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P273 Avoid release to the environment. 避免释放到环境中。
P301+P312
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Packing GroupIII