5-((2-Fluoro-4-Iodophenyl)Amino)-N-(2-Hydroxyethoxy)Imidazo[1,5-A]Pyridine-6-Carboxamide 5-((2-氟-4-碘苯基)氨基)-N-(2-羟基乙氧基)咪唑并[1,5-a]吡啶-6-甲酰胺
CAS 1168091-68-6 MFCD268091686
化学结构图
SMILES: O=C(NOCCO)c1ccc2cncn2c1Nc1ccc(I)cc1F
化学属性
| Mol. Weight | 456.21 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | 5-((2-Fluoro-4-Iodophenyl)Amino)-N-(2-Hydroxyethoxy)Imidazo[1,5-A]Pyridine-6-Carboxamide |
|---|---|
| Formula | C16H14FIN4O3 |
| Synonym | GDC0623; GDC-0632; GDC 0632; G868; G 868; G-868. |
| IUPAC Name | 5-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide |
| InChIKey | RFWVETIZUQEJEF-UHFFFAOYSA-N |
| InChI | InChI=1S/C16H14FIN4O3/c17-13-7-10(18)1-4-14(13)20-15-12(16(24)21-25-6-5-23)3-2-11-8-19-9-22(11)15/h1-4,7-9,20,23H,5-6H2,(H,21,24) |
| Canonical SMILES | O=C(C1=C(NC2=CC=C(I)C=C2F)N3C(C=C1)=CN=C3)NOCCO |
| Chemical Name Translation | 5-((2-氟-4-碘苯基)氨基)-N-(2-羟基乙氧基)咪唑并[1,5-a]吡啶-6-甲酰胺 |
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产品应用
- GDC-0623, also known as G-868, is an orally active, selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor GDC-0623 specifically inhibits mitogen-activated protein kinase kinase (MEK or MAP/ERK kinase), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
