6-(4-(Trifluoromethoxy)Phenyl)-3-(Trifluoromethyl)-[1,2,4]Triazolo[4,3-A]Pyridine 6-(4-(三氟甲氧基)苯基)-3-(三氟甲基)-[1,2,4]三唑并[4,3-a]吡啶
CAS 1262618-39-2 MFCD28385879
化学结构图
SMILES: FC(F)(F)Oc1ccc(-c2ccc3nnc(C(F)(F)F)n3c2)cc1
化学属性
| Mol. Weight | 347.22 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | 6-(4-(Trifluoromethoxy)Phenyl)-3-(Trifluoromethyl)-[1,2,4]Triazolo[4,3-A]Pyridine |
|---|---|
| Formula | C14H7F6N3O |
| Synonym | GS967; GS-967; GS 967; GS458967; GS 458967; GS-458967 |
| IUPAC Name | 6-(4-(trifluoromethoxy)phenyl)-3-(trifluoromethyl)(1,2,4)triazolo(4,3-a)pyridine |
| InChIKey | FEVBKJITJDHASC-UHFFFAOYSA-N |
| InChI | InChI=1S/C14H7F6N3O/c15-13(16,17)12-22-21-11-6-3-9(7-23(11)12)8-1-4-10(5-2-8)24-14(18,19)20/h1-7H |
| Canonical SMILES | FC(C1=NN=C2C=CC(C3=CC=C(OC(F)(F)F)C=C3)=CN21)(F)F |
| Chemical Name Translation | 6-(4-(三氟甲氧基)苯基)-3-(三氟甲基)-[1,2,4]三唑并[4,3-a]吡啶 |
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产品应用
- GS967, also known as GS-458967, is a highly selective late sodium channel current blocker. The selective inhibition of late INa with GS967 can exert antiarrhythmic effects by suppressing EAD- and DAD-mediated extrasystolic activity in PFs and PV and SVC sleeve preparations. Selective late INa inhibition with GS967 exerts potent protective effects against ischemia-induced depolarization and repolarization abnormalities in both atria and ventricles.
