N,N-Dicyclopropyl-4-((1,5-Dimethyl-1H-Pyrazol-3-Yl)Amino)-6-Ethyl-1-Methyl-1,6-Dihydroimidazo[4,5-D]Pyrrolo[2,3-B]Pyridine-7-Carboxamide N,N-二环丙基-4-((1,5-二甲基-1H-吡唑-3-基)氨基)-6-乙基-1,6-二氢-1-甲基-咪唑并[4,5-d]吡咯并[2,3-b]吡啶-7-甲酰胺
CAS 1271022-90-2 MFCD371022902
化学结构图
SMILES: CCn1c(C(=O)N(C2CC2)C2CC2)cc2c3c(ncn3C)c(Nc3cc(C)n(C)n3)nc21
化学属性
| Mol. Weight | 432.52142 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | N,N-二环丙基-4-((1,5-二甲基-1H-吡唑-3-基)氨基)-6-乙基-1,6-二氢-1-甲基-咪唑并[4,5-d]吡咯并[2,3-b]吡啶-7-甲酰胺 |
|---|---|
| Chemical Name | N,N-Dicyclopropyl-4-((1,5-Dimethyl-1H-Pyrazol-3-Yl)Amino)-6-Ethyl-1-Methyl-1,6-Dihydroimidazo[4,5-D]Pyrrolo[2,3-B]Pyridine-7-Carboxamide |
| Formula | C23H28N8O |
| Synonym | BMS911543; BMS-911543; BMS 911543. |
| IUPAC Name | N,N-dicyclopropyl-4-((1,5-dimethyl-1H-pyrazol-3-yl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide |
| InChIKey | JCINBYQJBYJGDM-UHFFFAOYSA-N |
| InChI | InChI=1S/C23H28N8O/c1-5-30-17(23(32)31(14-6-7-14)15-8-9-15)11-16-20-19(24-12-28(20)3)21(26-22(16)30)25-18-10-13(2)29(4)27-18/h10-12,14-15H,5-9H2,1-4H3,(H,25,26,27) |
| Canonical SMILES | O=C(C1=CC2=C(N(C)C=N3)C3=C(NC4=NN(C)C(C)=C4)N=C2N1CC)N(C5CC5)C6CC6 |
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产品应用
- BMS-911543 is an orally available small molecule targeting a subset of Janus-associated kinase (JAK) with potential antineoplastic activity. JAK2 inhibitor BMS-911543 selectively inhibits JAK2, thereby preventing the JAK/STAT (signal transducer and activator of transcription) signaling cascade, including activation of STAT3. This may lead to an induction of tumor cell apoptosis and a decrease in cellular proliferation. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival.
