HAC-Y6
CAS 1331959-78-4 MFCD431959784
化学结构图
SMILES: COc1cc(Cn2c3ccc(C(C)=O)cc3c3cccnc32)cc(OC)c1OC
化学属性
| Mol. Weight | 390.43 |
|---|---|
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | HAC-Y6 |
|---|---|
| Formula | C23H22N2O4 |
| Synonym | HACY6; HAC-Y6; HAC Y6. |
| IUPAC Name | 1-(9-(3,4,5-trimethoxybenzyl)-9H-pyrido[2,3-b]indol-6-yl)ethanone |
| InChIKey | NYMMDHGEECPYAW-UHFFFAOYSA-N |
| InChI | InChI=1S/C23H22N2O4/c1-14(26)16-7-8-19-18(12-16)17-6-5-9-24-23(17)25(19)13-15-10-20(27-2)22(29-4)21(11-15)28-3/h5-12H,13H2,1-4H3 |
| Canonical SMILES | CC(C1=CC2=C(N(CC3=CC(OC)=C(OC)C(OC)=C3)C4=NC=CC=C42)C=C1)=O |
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产品应用
- HAC-Y6 is a novel and potent microtubule inhitor. HAC-Y60 exhibited potent antitumor activity against human hepatocellular carcinoma (HCC) cells in vitro. Western blot and immunofluorescence experiments showed that HAC-Y6 depolymerized microtubules similarly to the effects of colchicine. HAC-Y6 exhibited its antitumor activity by disrupting microtubule assembly, causing cell cycle arrest and apoptosis through both extrinsic and intrinsic pathways in Hep3B cells. ( Oncol Rep. 2010 Nov;24(5):1169-78. )
