(endo-N-8-Methyl-8-azabicyclo-(3.2.1)oct-3-yl)-2,3-dihydro-3-isopropyl-2-oxo-1H-benzimidazol-1-carboxamide
CAS 134296-40-5 MFCD34296405
化学结构图
SMILES: Cl.CN1[C@@H]2CC(C[C@@H]1CC2)NC(=O)[n]1c2ccccc2[n](C(C)C)c1=O
化学属性
| Mol. Weight | 378.90 (anhydrous basis) |
|---|---|
| Mol. Formula | C19H26N4O2·HCl · xH2O |
别名和识别编码
| Synonym | 2,3-Dihydro-N-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-3-(1-methylethyl)-2-oxo-1H-benzimidazole-1-carboxamide Hydrochloride (1:1) hydrate |
|---|---|
| CAS Number | 134296-40-5 (anhydrous) |
| InChIKey | NQYXXIUVFVOJCX-UHFFFAOYSA-N |
| Chemical Name | BIMU8 hydrate |
| PubChem Substance ID | 329773228 |
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分类
- Agonists, B, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Proteins and Derivatives, Serotonergics, Serotonergics - Agonists
- {SNA} Agonists, B, Bioactive Small Molecule Alphabetical Index, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Serotonergics,
相关文献及参考
- Pellissier, L.P., et al., Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. Mol. Pharmacol. 75 , 982-990, (2009) 摘要
- Bickmeyer, U., et al. , Differential modulation of I(h) by 5-HT receptors in mouse CA1 hippocampal neurons. Eur. J. Neurosci. 16 , 209-218, (2002) 摘要
- Ponimaskin, E.G., et al., 5-Hydroxytryptamine 4(a) receptor expressed in Sf9 cells is palmitoylated in an agonist-dependent manner. Biochem. J. 353 , 627-634, (2001) 摘要
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
