Methyl 2-Benzamido-1-(3-Phenylpropyl)-1H-Benzo[D]Imidazole-5-Carboxylate 2-苯甲酰胺基-1-(3-苯丙基)-1H-苯并[d]咪唑-5-羧酸甲酯
CAS 1374601-40-7 MFCD474601407
化学结构图
SMILES: COC(=O)c1ccc2c(c1)nc(NC(=O)c1ccccc1)n2CCCc1ccccc1
化学属性
| Mol. Weight | 413.47 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | 2-苯甲酰胺基-1-(3-苯丙基)-1H-苯并[d]咪唑-5-羧酸甲酯 |
|---|---|
| Chemical Name | Methyl 2-Benzamido-1-(3-Phenylpropyl)-1H-Benzo[D]Imidazole-5-Carboxylate |
| Formula | C25H23N3O3 |
| Synonym | BRD4770; BRD-4770; BRD 4770. |
| IUPAC Name | methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate |
| InChIKey | UCGWYCMPZXDHNR-UHFFFAOYSA-N |
| InChI | InChI=1S/C25H23N3O3/c1-31-24(30)20-14-15-22-21(17-20)26-25(27-23(29)19-12-6-3-7-13-19)28(22)16-8-11-18-9-4-2-5-10-18/h2-7,9-10,12-15,17H,8,11,16H2,1H3,(H,26,27,29) |
| Canonical SMILES | O=C(C1=CC=C2C(N=C(NC(C3=CC=CC=C3)=O)N2CCCC4=CC=CC=C4)=C1)OC |
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产品应用
- BRD4770 is a novel histone methyltransferase inhibitor. BRD4770 reduced cellular levels of di- and trimethylated H3K9 without inducing apoptosis, induced senescence, and inhibited both anchorage-dependent and -independent proliferation in the pancreatic cancer cell line PANC-1. ATM-pathway activation, caused by either genetic or small-molecule inhibition of G9a, may mediate BRD4770-induced cell senescence. BRD4770 may be a useful tool to study G9a and its role in senescence and cancer cell biology.
