SP-2509 (E)-N'-(1-(5-氯-2-羟基苯基)亚乙基)-3-(吗啉磺酰)苯并酰肼
CAS 1423715-09-6 MFCD523715096
化学结构图
SMILES: C/C(=N\NC(=O)c1cccc(S(=O)(=O)N2CCOCC2)c1)c1cc(Cl)ccc1O
化学属性
| Mol. Weight | 437.9 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | SP-2509 |
|---|---|
| Formula | C19H20ClN3O5S |
| Synonym | SP2509; SP 2509; SP-2509. |
| IUPAC Name | (E)-N'-(1-(5-chloro-2-hydroxyphenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide. |
| InChIKey | NKUDGJUBIVEDTF-FYJGNVAPSA-N |
| InChI | InChI=1S/C19H20ClN3O5S/c1-13(17-12-15(20)5-6-18(17)24)21-22-19(25)14-3-2-4-16(11-14)29(26,27)23-7-9-28-10-8-23/h2-6,11-12,24H,7-10H2,1H3,(H,22,25)/b21-13+ |
| Canonical SMILES | O=C(N/N=C(C1=CC(Cl)=CC=C1O)\C)C2=CC=CC(S(=O)(N3CCOCC3)=O)=C2 |
| Chemical Name Translation | (E)-N'-(1-(5-氯-2-羟基苯基)亚乙基)-3-(吗啉磺酰)苯并酰肼 |
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产品应用
- SP-2509 is a novel histone demethylase LSD1 inhibitor, which showed high actitivity on human AML cells. Treatment with the novel LSD1 antagonist SP2509 attenuated the binding of LSD1 with the corepressor CoREST, increased the permissive H3K4Me3 mark on the target gene promoters, and increased the levels of p21, p27 and CCAAT/enhancer binding protein α in cultured AML cells. In addition, SP2509 treatment or LSD1 shRNA inhibited the colony growth of AML cells.
