1-((2’-(1H-Tetrazol-5-Yl)-[1,1’-Biphenyl]-4-Yl)Methyl)-4-(2-Hydroxypropan-2-Yl)-2-Propyl-1H-Imidazole-5-Carboxylic Acid 1-((2’-(1H-四唑-5-基)-[1,1’-联苯]-4-基)甲基)-4-(2-羟丙基-2-基)-2-丙基-1H-咪唑-5-羧酸
CAS 144689-24-7 MFCD44689247
化学结构图
SMILES: CCCC1=NC(=C(C(O)=O)N1CC1C=CC(=CC=1)C1C=CC=CC=1C1=NNN=N1)C(C)(C)O
化学属性
| Mol. Weight | 446.5 |
|---|---|
| Mol. Formula | C24H26N6O3 |
别名和识别编码
| CAS Number | 144689-24-7 |
|---|---|
| Chemical Name | 1-((2’-(1H-Tetrazol-5-Yl)-[1,1’-Biphenyl]-4-Yl)Methyl)-4-(2-Hydroxypropan-2-Yl)-2-Propyl-1H-Imidazole-5-Carboxylic Acid |
| Synonym | 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2?-(1H-tetazol-5-yl)[1,1?-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid CS 088 RNH 6270 |
| Chemical Name Translation | 1-((2’-(1H-四唑-5-基)-[1,1’-联苯]-4-基)甲基)-4-(2-羟丙基-2-基)-2-丙基-1H-咪唑-5-羧酸 |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- Nucleotides
- Bases & Related Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- An angiotensin II receptor antagonist. Used as an anti-hypertensive.
相关文献及参考
- [2]. Tanno T, et al. Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression. J Cardiovasc Pharmacol. 2016 Jun;67(6):503-9.
- [3]. Bakhtiari E, et al. Synergistic, cytotoxic and apoptotic activities of olmesartan with NF-κB inhibitor against HeLa human cell line. Toxicol Mech Methods. 2015;25(8):614-21.
- Puchler, K., et al.: J. Hypertens., 15, 1809 (1997),
- Yanagisawa, H., et al.: J. Med. Chem., 39, 323 (1996),
- [1]. Yanagihara H, et al. Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet. J Pharmacol Sci. 2016 Jul;131(3):190-7.
- [1]. Yanagihara H, et al. Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet. J Pharmacol Sci. 2016 Jul;131(3):190-7.
- [2].
安全信息
GHS Symbol
