1-(3,3-Dimethylbutyl)-3-(2-Fluoro-4-Methyl-5-(7-Methyl-2-(Methylamino)Pyrido[2,3-D]Pyrimidin-6-Yl)Phenyl)Urea 1-(3,3-二甲基丁基)-3-(2-氟-4-甲基-5-(7-甲基-2-(甲胺基)吡啶并[2,3-d]嘧啶-6-基)苯基)脲
CAS 1454682-72-4 MFCD554682724
化学结构图
SMILES: CNc1ncc2cc(-c3cc(NC(=O)NCCC(C)(C)C)c(F)cc3C)c(C)nc2n1
化学属性
| Mol. Weight | 424.52 |
|---|---|
| Appearance | Light yellow solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | 1-(3,3-二甲基丁基)-3-(2-氟-4-甲基-5-(7-甲基-2-(甲胺基)吡啶并[2,3-d]嘧啶-6-基)苯基)脲 |
|---|---|
| Chemical Name | 1-(3,3-Dimethylbutyl)-3-(2-Fluoro-4-Methyl-5-(7-Methyl-2-(Methylamino)Pyrido[2,3-D]Pyrimidin-6-Yl)Phenyl)Urea |
| Formula | C23H29FN6O |
| Synonym | LY3009120; LY-3009120; LY 3009120; DP4978; DP 4978; DP-4978. |
| IUPAC Name | 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea |
| InChIKey | HHCBMISMPSAZBF-UHFFFAOYSA-N |
| InChI | InChI=1S/C23H29FN6O/c1-13-9-18(24)19(29-22(31)26-8-7-23(3,4)5)11-16(13)17-10-15-12-27-21(25-6)30-20(15)28-14(17)2/h9-12H,7-8H2,1-6H3,(H2,26,29,31)(H,25,27,28,30) |
| Canonical SMILES | O=C(NC1=CC(C2=CC3=CN=C(NC)N=C3N=C2C)=C(C)C=C1F)NCCC(C)(C)C |
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产品应用
- LY3009120, also known as DP-4978, is potent and selective pan-RAF inhibitor with potential anticancer activity. LY3009120 showed activities against BRaf or Ras mutant tumor cells . LY3009120 binds to ARaf, BRaf and CRaf isoforms with similar affinity in cells with activating mutations of BRaf or KRas. LY3009120 induces minimal paradoxical pathway activation in NRas or KRas mutant cells. LY3009120 inhibits MEK phosphorylation and cell proliferation in vitro, and exhibits anti-tumor activity in multiple xenograft models carrying mutations in BRaf, NRas or KRas.
