(R)-4-((3-Chloro-2-Fluorophenyl)Amino)-7-Methoxyquinazolin-6-Yl 2,4-Dimethylpiperazine-1-Carboxylate (R)-4-((3-氯-2-氟苯基)氨基)-7-甲氧基喹唑啉-6-基-2,4-二甲基哌嗪-1-羧酸酯
CAS 1626387-80-1 MFCD726387801
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- AZD3759 is also known as zorifertinib. It is an orally available inhibitor of the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, AZD3759 binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR. This prevents EGFR-mediated signaling, and may lead to both induction of cell death and inhibition of tumor growth in EGFR-overexpressing cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.