(R)-8-(1-((3,5-Difluorophenyl)Amino)Ethyl)-N,N-Dimethyl-2-Morpholino-4-Oxo-4H-Chromene-6-Carboxamide (R)-8-(1-((3,5-二氟苯基)氨基)乙基)-N,N-二甲基-2-吗啉-4-氧代-4H-苯并吡喃-6-甲酰胺
CAS 1627494-13-6 MFCD727494136
化学结构图
SMILES: C[C@@H](Nc1cc(F)cc(F)c1)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12
化学属性
| Mol. Weight | 457.4 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | (R)-8-(1-((3,5-二氟苯基)氨基)乙基)-N,N-二甲基-2-吗啉-4-氧代-4H-苯并吡喃-6-甲酰胺 |
|---|---|
| Chemical Name | (R)-8-(1-((3,5-Difluorophenyl)Amino)Ethyl)-N,N-Dimethyl-2-Morpholino-4-Oxo-4H-Chromene-6-Carboxamide |
| Formula | C24H25F2N3O4 |
| Synonym | AZD8186; AZD 8186; AZD-8186. |
| IUPAC Name | (R)-8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide |
| InChIKey | LMJFJIDLEAWOQJ-CQSZACIVSA-N |
| InChI | InChI=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3)9-20-21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3/t14-/m1/s1 |
| Canonical SMILES | O=C(N(C)C)C1=CC([C@@H](C)NC2=CC(F)=CC(F)=C2)=C3C(C(C=C(O3)N4CCOCC4)=O)=C1 |
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产品应用
- AZD8186 is and inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic activity. Upon administration, PI3Kbeta inhibitor AZD8186 selectively inhibits the activity of PI3Kbeta in the PI3K/Akt/mTOR signaling pathway, which may result in a decrease of tumor cell proliferation. It also induces cell death in PI3K-expressing cancer cells. By specifically targeting class I PI3K beta, this agent may be more efficacious and less toxic than pan PI3K inhibitors. PI3K-mediated signaling is often dysregulated in cancer cells and contributes to increased tumor cell growth, survival, and tumor resistance to a variety of antineoplastic agents. AZD8186 is currently under Phase I clinical trials.
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