2-Hydroxy Atorvastatin Lactone
CAS 163217-74-1 MFCD63217741
化学结构图
SMILES: [2H]C1=C(C2C(=C(C(C)C)N(CC[C@@H]3C[C@@H](O)CC(=O)O3)C=2C2C=CC(F)=CC=2)C(=O)NC2=CC=CC=C2O)C([2H])=C([2H])C([2H])=C1[2H]
化学属性
| Mol. Weight | 556.62 |
|---|---|
| Mol. Formula | C33H33FN2O5 |
别名和识别编码
| CAS Number | 163217-74-1 |
|---|---|
| Chemical Name | 2-Hydroxy Atorvastatin Lactone |
| Synonym | 5-(4-Fluorophenyl)-N-(2-hydroxyphenyl)-2-(1-methylethyl)-4-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide |
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分类
- Metabolites,
产品应用
- A metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and trig
相关文献及参考
- [2]. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61.
- [1]. Guo CX, et al. Effects of Ginkgo biloba extracts on pharmacokinetics and efficacy of atorvastatin based on plasma indices. Xenobiotica. 2012;42(8):784‐790.
- [1]. Guo CX, et al. Effects of Ginkgo biloba extracts on pharmacokinetics and efficacy of atorvastatin based on plasma indices. Xenobiotica. 2012;42(8):784‐790.
- [2]. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61.
