4-((5,5-Dimethyl-8-(P-Tolyl)-5,6-Dihydronaphthalen-2-Yl)Ethynyl)Benzoic Acid 4-[2-[5,6-二氢-5,5-二甲基-8-(4-甲基苯基)-2-萘基]炔基]苯甲酸
CAS 171746-21-7 MFCD71746217
化学结构图
SMILES: Cc1ccc(C2=CCC(C)(C)c3ccc(C#Cc4ccc(C(=O)O)cc4)cc32)cc1
化学属性
| Mol. Weight | 392.49 |
|---|---|
| Mol. Formula | C28H24O2 |
别名和识别编码
| CAS Number | 171746-21-7 |
|---|---|
| Chemical Name | 4-((5,5-Dimethyl-8-(P-Tolyl)-5,6-Dihydronaphthalen-2-Yl)Ethynyl)Benzoic Acid |
| Synonym | 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]benzoic Acid CD 3106 |
| Chemical Name Translation | 4-[2-[5,6-二氢-5,5-二甲基-8-(4-甲基苯基)-2-萘基]炔基]苯甲酸 |
| LabNetwork Molecule ID | LN04612288 |
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分类
- Aromatics
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- A retinoic acid receptor (RAR) antagonist used for treating chemotherapy and radiation therapy side effects.
相关文献及参考
- [2]. Agarwal C, et al. AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells. J Biol Chem. 1996 May 24;271(21):12209-12.
- [3]. Standeven AM, et al. Specific antagonist of retinoid toxicity in mice. Toxicol Appl Pharmacol. 1996 May;138(1):169-75.
- Johnson, A., et al.: J. Med. Chem., 38, 4764
- [1]. Johnson AT, et al. Synthesis and characterization of a highly potent and effective antagonist of retinoic acid receptors. J Med Chem. 1995 Nov 24;38(24):4764-7.
- [1]. Johnson AT, et al. Synthesis and characterization of a highly potent and effective antagonist of retinoic acid receptors. J Med Chem. 1995 Nov 24;38(24):4764-7.
- [2]. Agarwal C, et al. AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells. J Biol Chem. 1996 May 24;271(21):12209-12.
- [3]. Standeven AM, et al. Specific antagonist of retinoid toxicity in mice. Toxicol Appl Pharmacol. 1996
