Spisulosine, also known as ES-285, is novel compound derived from the marine mollusk Spisula polynoma with evidence of preclinical antitumor activity. Phase I clinical trial results: Dose level VIII (200 mg/m(2)) was considered the MTD, and dose level IX (160 mg/m(2)) was defined as the RD. Limited antitumor activity was observed.
CAS 196497-48-0 MFCD96497480
化学结构图
SMILES: CCCCCCCCCCCCCCCC(O)[C@@H](C)N
化学属性
| Mol. Weight | 285.51 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | Spisulosine, also known as ES-285, is novel compound derived from the marine mollusk Spisula polynoma with evidence of preclinical antitumor activity. Phase I clinical trial results: Dose level VIII (200 mg/m(2)) was considered the MTD, and dose level IX (160 mg/m(2)) was defined as the RD. Limited antitumor activity was observed. |
|---|---|
| Formula | C18H39NO |
| Synonym | ES285; ES285; Spisulosine . |
| IUPAC Name | (2R)-2-aminooctadecan-3-ol |
| InChIKey | YRYJJIXWWQLGGV-QNSVNVJESA-N |
| InChI | InChI=1S/C18H39NO/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18(20)17(2)19/h17-18,20H,3-16,19H2,1-2H3/t17-,18?/m1/s1 |
| Canonical SMILES | C[C@@H](N)C(O)CCCCCCCCCCCCCCC |
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- Spisulosine, also known as ES-285, is novel compound derived from the marine mollusk Spisula polynoma with evidence of preclinical antitumor activity. Phase I clinical trial results: Dose level VIII (200 mg/m(2)) was considered the MTD, and dose level IX (160 mg/m(2)) was defined as the RD. Limited antitumor activity was observed.
