(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol hemi((3-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonate) 福沙吡坦二甲葡胺
CAS 265121-04-8 MFCD65121048
化学结构图
SMILES:
化学属性
| Mol. Weight | 1,004.83 |
|---|---|
| Mol. Formula | C37H56F7N6O16P |
别名和识别编码
| CAS Number | 265121-04-8 |
|---|---|
| Chemical Name | (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol hemi((3-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonate) |
| Synonym | [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate 1-Deoxy-1-(methylamino)-D-glucitol MK 0517 |
| Chemical Name Translation | 福沙吡坦二甲葡胺 |
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分类
- Aromatics
- Chiral Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Phosphorylating and Phosphitylating Agents
产品应用
- Fosaprepitant is a selective neurokinin-1 (NK-1) receptor antahonist. Fosaprepitant is an antiemetic drug, a Aprepitant (A729800) prodrug.
相关文献及参考
- Cocquyt, V., et al.: Eur. J. Canc., 37, 835 (2001),
- Tattersall, F., et al.: Neuropharmacol., 39, 652 (2000),
- [1]. Pranav Prasoon, et al. Role of fosaprepitant, a neurokinin Type 1 receptor antagonist, in morphine-induced antinociception in rats. Indian J Pharmacol. 2016 Jul-Aug; 48(4): 394-398.
